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Article source: Medical Rubik's Cube Pro
B7-H3 is a member of the B7 family of immunoregulatory molecules.
B7-H3 mechanism of action (Source: MacroGenics)
B7-H3 mechanism of action (Source: MacroGenics)MGC018 is an ADC targeting B7-H3, formed by anti-B7-H3 humanized IgG1/kappa monoclonal antibody through a cleavable linker coupled to the prodrug seco-DUocarmycin hydroxyBenzamide Azaindole (DUBA), with an average DAR of ~2.
MGC018 structure (Source: MacroGenics)
MGC018 structure (Source: MacroGenics)At the 2021 ASCO annual meeting, the biopharmaceutical company MacroGenics announced the preliminary safety and anti-tumor activity data of the ongoing phase I dose-escalation clinical trial of MGC018 (NCT03729596)
mCRPC patient data (Source: MacroGenics)
mCRPC patient data (Source: MacroGenics)The results of the analysis showed that MGC018 showed preliminary evidence of anti-tumor activity, especially in patients with advanced metastatic castration-resistant prostate cancer (mCRPC), and 5 out of 9 mCRPC patients had prostate-specific antigen observed during dose escalation therapy.
Melanoma patient data (Source: MacroGenics)
Melanoma patient data (Source: MacroGenics)During the dose escalation process, 3 melanoma patients received 4.
Safety data (Source: MacroGenics)
Safety data (Source: MacroGenics)In terms of safety, as of May 3, 2021, in the 0.
Preclinical data of combined PD-1 antibody (Source: MacroGenics)
Preclinical data of combined PD-1 antibody (Source: MacroGenics)In addition to the above data, MacroGenics also announced the preclinical research data of MGC018 combined with PD-1 antibody
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Reference materials:
Reference materials:1# MacroGenics Announces Preliminary Clinical Results from Phase 1 Study of MGC018 to be Presented at ASCO Annual Meeting (Source: MacroGenics)
1# MacroGenics Announces Preliminary Clinical Results from Phase 1 Study of MGC018 to be Presented at ASCO Annual Meeting (Source: MacroGenics)