Bacterial indoles as multifunctional modulators of complex enterotoxicity in Klebsiella oxytocins

Gastrointestinal microbes respond to biochemical metabolites that coordinate their behavior

Here we demonstrate that bacterial indole is a multifactorial mitigating factorKlebsiella grimonisandKlebsiella oxytogensPathogenicity

The human gut has a complex microbial community that includes species and strains that may be symbionts or pathogens, depending on the environment

In this environment, microbe-host microbe interactions are important for maintaining homeostasis (1,2) in the gut ecosystem, due to changes in factors such as diet, antibiotics, and host susceptibility, can lead to abnormal biological conditions, in which resident microbes adopt pathogenic behaviors and cause disease (three,4).

5–9) while enhancing the host intestinal barrier (10) indole and indole derivatives can also activate intestinal exogenous receptors such as pregnane X receptor (PXR) (11), helps fight inflammation (12) and detoxification (13) respond

Considered a human gut commensal, but overgrowth of cytotoxin-producing bacteria in older children and adults treated with beta-lactam antibioticsK.

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MongrierandK.
to induce laborBy inhibiting the synthesis of doxorubicin, it enhances its conversion to tiverine, while activating the host nuclear receptor PXR
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We determined that tilivarine is a strong agonist of PXR;This interaction upregulates PXR-responsive detoxification genes and alleviates tubulin acetylation
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Our findings reinforce the notion that gut microbe-produced metabolites are key mediators of microbial and host microbial crosstalk
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