Bacterial lipid droplets protect DNA and are involved in DNA transcription regulation.

On July 6, 2017, Nature Communications published online a research paper by Liu Pingsheng of the Institute of Biophysics of the Chinese Academy of Sciences ("Ric lid droplets bind to DNA via an an international protein the enhances survival under stress").
article describes the important findings of the team: bacterial lipid droplets can bind and protect genomic DNA through their main protein, MLDSS, and participate in transcription regulation through MLDSR proteins, thus helping bacteria survive in extreme environments.
lipid droplets are globulin cells that are made of neutral lipids, covered by a single layer of phospholipid membranes and epuralin. the specificity of
fat drop single layer phospholipid membrane, especially the specific recognition of lipid droplets, indicates that lipid droplets are very special in cells and different from other bispholipid membrane cell structure.
the emergence of bacterial lipid droplets, providing bacteria with a new way of cellular partition different from cytosynthic membranes.
work of Liu Pingsheng's team revealed the lipid and protein composition of bacterial lipid droplets, and found a protein that controls the size of lipid droplets and named it MLDS.
the team's recent breakthrough in research that found and demonstrated that bacterial lipid droplets bind to bacterial genomic DNA through MLDS and protect genomic DNA in extreme environments, thereby improving bacterial survival.
in the study of the regulation mechanism of this important physiological process, Liu Pingsheng's research team further revealed that bacterial lipid droplets not only protect DNA, but also participate in DNA transcription control by controlling the effective concentration of transcription factors.
this study shows that bacterial lipid droplets, through their single-layer phosphorid membrane specificity, store triglycerides and bind to genomic DNA, thereby improving the effectiveness and specificity of the two major factors that determine life - metabolism and genetics.
therefore, the emergence of bacterial lipid droplets, possibly the prototype of the original nuclei, is an important milestone in the evolution of cells from the nuclei to the ethons.
Researcher Liu Pingsheng is the communication author of this paper, and Zhang Congxuan, Ph.D. student of Liu Pingsheng's research group, is the first author of this paper.
this work is funded by the national key projects and surface projects of the National Natural Science Foundation of China, the Special Class A of Strategic Pilot Science and Technology of the Chinese Academy of Sciences, and the National Key Research and Development Program of the Ministry of Science and Technology of China.
two patents have been applied for in the relevant research work.
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