Banna miniature pig makes a sensation in the whole academic circle

Introduction: after more than 20 years of inbreeding, a Chinese pig has produced a series of miraculous variations, its weight has also been reduced from more than 50 kg of the first generation to more than 10 kg, and the performance of its offspring is amazing The research results of Banna miniature pig inbred line by Zeng Yangzhi, Professor of Yunnan Agricultural University, caused a stir in the academic circles at the international genome conference held recently in Hangzhou Experts believe that this epoch-making genetic miracle will provide new ideas for human gene research The study of inbred lines of animals is to breed the offspring of a whole sib continuously among the close relatives of an animal The purpose is to breed a pure line from the same pair of ancestors, highly homozygous genes, clear genetic background and close to zero individual differences For many years, inbreeding animals have become an indispensable experiment in the biomedical field, widely used in pharmacology, pathology, xenotransplantation, functional genes and other research Therefore, since the 1920s, the United States, Britain and other countries have carried out more than 200 pig inbreeding experiments, but all of them failed because of severe deformity, premature death and other inbreeding decline Therefore, scientists believe that it is impossible to breed inbred lines of pigs In 1977, Professor Zeng Yangzhi took aim at this world problem and found a nest of Xishuangbanna miniature pigs which were the most suitable for inbreeding research in the villages along the border between China and Thailand Since then, he has started the inbreeding experiment of miniature pigs for more than 20 years So far, it has been inbred to the 19th generation, not only two inbred lines with different size and genotype, but also 18 sub lines with different phenotypic characteristics and genetic markers According to the slides presented by Professor Zeng, each generation of inbred pigs shows different genetic characteristics Some bristles stand upright, some tusks stand out, some spots are beautiful This shows that some genes that lurk in the body can appear in "Incest", and the progeny type of pigs is also shrinking due to inbreeding Experts agree that pigs are the most similar to humans in terms of genetic characteristics such as anatomy, physiology and metabolism Understanding the meaning of each gene in pigs will provide valuable reference for future biological experiments It is reported that by 2002, Zeng Yangzhi will complete this unique research work in the world Professor Zhao Shouyuan, President of the International Federation of genetics, believes that because Banna pig inbred lines are close to pure breeds and are unique precious resources in China, in addition to using them as experimental animals and genetic breeding, they will also lay a solid foundation for the development of functional genes, the expansion of gene industry, and even the research and application of the whole human genome project (author:) share to feed Weibo share to: