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In the tumor microenvironment, tumor cells can evade surveillance and clearance by the immune system through a variety of mechanisms
Previous studies have shown that extracellular matrix can not only affect the spatial organization of T cells by regulating their migration and adhesion, but also regulate their DNA synthesis and proliferation through receptors
In this study, the authors used bioinformatics methods to mine and analyze the TCGA database, and found that there is a correlation between the characteristic expression profiles of basement membrane and killer CD8 + T cell immune responses and type I anti-tumor immune responses in multiple tumor types.
Using models such as in vivo subcutaneous xenografts and in vitro T cell activation, this study found that basement membrane proteins can directly negatively regulate TCR signaling during tumor development and then downregulate T cell activation, proliferation, and function
Researcher Ge Gaoxiang and Chen Jianfeng from the Center of Excellence for Molecular Cells are the co-corresponding authors of the paper, and Liu Xiangming, a doctoral student in Ge Gaoxiang's group, is the first author of the paper
Article link: https://doi.
Pattern: Laminin inhibits the activation of T cells to promote tumorigenesis and development