Basic scientific research Nature is heavy: American wild white-tailed deer has carried three new crown variants, one of which is closely related to the epidemic in humans

This article is reproduced from the WeChat public account of "China Biotechnology Network"
.

This article is reproduced from the WeChat public account of "China Biotechnology Network"

 

On December 24, Beijing time, in a new study published in the top international academic journal Nature (currently an unedited manuscript), a research team from Ohio State University in the state of wild white-tailed deer (Odocoileus virginianus) At least three mutated strains of the new coronavirus have been found in the virus, suggesting that this species may be a potential "reservoir" for the new coronavirus
.

This means that the new coronavirus can survive in wild white-tailed deer for a long time, opening up new ways for its further transformation and possible transmission to humans

On December 24, Beijing time, in a new study published in the top international academic journal Nature (currently an unedited manuscript), a research team from Ohio State University in the state of wild white-tailed deer (Odocoileus virginianus) At least three mutated strains of the new coronavirus have been found in the virus, suggesting that this species may be a potential "reservoir" for the new coronavirus

 

 

In the past two years, reports from different countries have confirmed that humans can transmit the new coronavirus to a variety of mammals, including primates, cats, dogs, minks, and hippos, but no new natural animal host has been observed.

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In the past two years, reports from different countries have confirmed that humans can transmit the new coronavirus to a variety of mammals, including primates, cats, dogs, minks, and hippos, but no new natural animal host has been observed.
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Previous research led by the United States Department of Agriculture has confirmed the presence of new coronavirus antibodies in wild white-tailed deer populations in Iowa, United States
.

This fact raises many new unanswered questions, including how did the deer get infected? Can they infect humans and other species? Are they a temporary infection or a long-term infection?

Previous research led by the United States Department of Agriculture has confirmed the presence of new coronavirus antibodies in wild white-tailed deer populations in Iowa, United States

 

In this new study, the researchers collected nasal swabs from 360 wild white-tailed deer from 9 different locations in northeastern Ohio between January and March 2021.

Each location was sampled 1 to 3 times

In this new study, the researchers collected nasal swabs from 360 wild white-tailed deer from 9 different locations in northeastern Ohio between January and March 2021.
Each location was sampled 1 to 3 times

 

 

Through nucleic acid testing, the researchers detected three different new coronavirus lineages B.

1.
2, B.
1.

Through nucleic acid testing, the researchers detected three different new coronavirus lineages B.
1.
2, B.
1.
582 and B.
1.
596 in 129 (35.
8%) sampled deer
.

 

 

Researchers estimate that among the deer in 9 locations, the new coronavirus infection rate is between 13.
5-70%
.
The prevalence is highest in the four locations around the more densely populated communities
.

Researchers estimate that among the deer in 9 locations, the new coronavirus infection rate is between 13.
5-70%
.
The prevalence is highest in the four locations around the more densely populated communities
.

 

 

Genome sequencing revealed that the B.
1.
2 virus, which dominated Ohio's patients infected with new coronary pneumonia in the first few months of 2021, spilled into deer herds in different locations many times
.
B.
1.
2, B.
1.
582 and B.
1.
596 virus strains may have spread between deer and deer, allowing the virus to obtain spike protein (including receptor binding domain) and amino acid substitutions in ORF1, which are in humans.
Rare
.

Genome sequencing revealed that the B.
1.
2 virus, which dominated Ohio's patients infected with new coronary pneumonia in the first few months of 2021, spilled into deer herds in different locations many times
.
B.
1.
2, B.
1.
582 and B.
1.
596 virus strains may have spread between deer and deer, allowing the virus to obtain spike protein (including receptor binding domain) and amino acid substitutions in ORF1, which are in humans.
Rare
.

 

 

 

Andrew Bowman, the corresponding author of the study and associate professor of veterinary preventive medicine at Ohio State University, said: "The analysis results show that humans have repeatedly transmitted 6 different strains to wild white-tailed deer
.
Our evidence shows that six different strains have been introduced.
Instead of spreading after being infected with a single strain
.
"

Andrew Bowman, the corresponding author of the study and associate professor of veterinary preventive medicine at Ohio State University, said: "The analysis results show that humans have repeatedly transmitted 6 different strains to wild white-tailed deer
.
Our evidence shows that six different strains have been introduced.
Instead of spreading after being infected with a single strain
.
"

 

 

 

Bowman believes that white-tailed deer as the host of the new coronavirus may cause two results
.
First, the new coronavirus may mutate in the white-tailed deer, thereby promoting the transmission of new mutant strains to other species including humans ; second, the virus can survive in the white-tailed deer without mutating, while continuing Evolving in humans, at a certain moment, when humans have no immunity to deer-infecting virus strains, these mutant strains may be passed back to humans
.

Bowman believes that white-tailed deer as the host of the new coronavirus may cause two results
.
First, the new coronavirus may mutate in the white-tailed deer, thereby promoting the transmission of new mutant strains to other species including humans ; second, the virus can survive in the white-tailed deer without mutating, while continuing Evolving in humans, at a certain moment, when humans have no immunity to deer-infecting virus strains, these mutant strains may be passed back to humans
.
White-tailed deer as the host of the new coronavirus may cause two results.
The new coronavirus may mutate in the white-tailed deer, thereby promoting the transmission of new mutant strains to other species, including humans.
The virus can be in the white-tailed condition without mutation.
Deer survive in the body while continuing to evolve in humans.
At a certain moment, when humans have no immunity to the virus strains that infect deer, these mutant strains may be passed back to humans.

 

 

Regarding how the initial cross-species transmission occurred, the team speculated that the white-tailed deer was infected through environmental means, such as drinking water contaminated by humans or contacting human garbage
.
Because the new coronavirus can be transmitted through the fecal mouth, it can also be detected in wastewater
.

Regarding how the initial cross-species transmission occurred, the team speculated that the white-tailed deer was infected through environmental means, such as drinking water contaminated by humans or contacting human garbage
.
Because the new coronavirus can be transmitted through the fecal mouth, it can also be detected in wastewater
.

 

 

Bowman said that the fact that white-tailed deer can be infected by the new coronavirus for a long time means that a new maintenance host may have been established outside of humans
.

Bowman said that the fact that white-tailed deer can be infected by the new coronavirus for a long time means that a new maintenance host may have been established outside of humans
.

 

 

It is estimated that the number of white-tailed deer in Ohio alone is about 600,000, while there are about 30 million white-tailed deer in the United States
.

It is estimated that the number of white-tailed deer in Ohio alone is about 600,000, while there are about 30 million white-tailed deer in the United States
.

 

 

The researchers said that white-tailed deer have not yet observed the transmission of the new coronavirus to humans, but these results indicate that the new coronavirus can be transmitted among wild animals in the United States, which may open up new paths for its evolution
.
Therefore, there is an urgent need to establish a comprehensive "One Health" plan to monitor deer, the environment, and other wildlife hosts around the world
.

The researchers said that white-tailed deer have not yet observed the transmission of the new coronavirus to humans, but these results indicate that the new coronavirus can be transmitted among wild animals in the United States, which may open up new paths for its evolution
.
Therefore, there is an urgent need to establish a comprehensive "One Health" plan to monitor deer, the environment, and other wildlife hosts around the world
.

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Reference materials:

Reference materials:

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