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BCMA targets: ADC and CART have been listed successively; double antibodies have failed again and again, Amgen and Pfizer have successively defeated BCMA/CD3 double antibodies

 Last Update: 2021-07-01
 Source: Internet
 Author: User

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On May 4, Pfizer announced the suspension of patient recruitment for the Phase 2 clinical trial MagnetisMM-3 of its BCMA/CD3 bispecific antibody elranatamab, due to 3 cases of peripheral nerve damage in the clinical trial
.

Previously, the Phase 1 clinical trial of the drug showed that the response rate was as high as 83%.

In early February of this year, Amgen announced the temporary termination of clinical studies of three bispecific antibody projects, including the BCMAXCD3 target bi-antibody drug AMG 701 (pavurutamab)
.

The main reason for the termination of AMG 701 was safety factors.

I used to think that in the peak competition of ADC, CAR-T and bispecific antibody on the BCMA target, BsAb would have the last laugh, but the result would be defeated again and again
.

Theoretically speaking, if CAR-T can succeed, BsAb has a great probability of success.

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