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    Home > Medical News > Medicines Company News > BeiGene Announces Interim Analysis Results of RATIONALE 303 Clinical Trial of Baizean for the Treatment of Second-line or Third-line Non-Small Cell Lung Cancer

    BeiGene Announces Interim Analysis Results of RATIONALE 303 Clinical Trial of Baizean for the Treatment of Second-line or Third-line Non-Small Cell Lung Cancer

    • Last Update: 2021-07-10
    • Source: Internet
    • Author: User
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    • In the ITT population, the median OS of the Bazin® test arm was 17.


      • In the Bazaan® test arm, 509 patients (95.
        3%) experienced at least one adverse event (TEAE) during treatment, the most common being anemia (28.
        5%) and elevated alanine aminotransferase (ALT; 19.
        9%) ) And cough (19.
        5%)
        .
        In contrast, in the docetaxel test arm, 254 patients (98.
        4%) experienced at least one TEAE, the most common being alopecia (47.
        3%), anemia (43.
        4%), and neutropenia (36.
        8%) )
      • 206 patients (38.
        6%) and 193 patients (74.
        8%) of the Bazaan® test arm and the docetaxel test arm experienced grade 3 and above TEAEs, respectively
      • 174 patients (32.
        6%) and 83 patients (32.
        2%) experienced severe TEAE in the test arm of Baizen® and the test arm of docetaxel, respectively
      • There were 56 patients (10.
        5%) and 32 patients (12.
        4%) in the Baznan® test arm and the docetaxel test arm, respectively, who discontinued the trial treatment due to TEAE
      • There were 32 patients (6%) and 11 patients (4.
        3%) died of TEAE in the test arm of Baizen® and the test arm of docetaxel, respectively.
      • In the Baizean® test arm, hypothyroidism (7.
        5%) and pneumonia (2.
        2%) were the most common immune-mediated TEAEs of any grade and grade 3 and above, respectively
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