Betagamma-CAT has the function of regulating the acidification environment of intracellular follicles.

Recently, the Journal of infectious diseases of the American Society of Infectious Diseases published online the latest research results of Zhang Yun group of the Kunming Institute of Zoology of the Chinese Academy of Sciences under the title of Host pore-forming protein complex neutralizes the acidification of the endocytic organelles to counteract intracellular pathogens.
The study reveals new strategies and effect molecules for vertebrates to defend and remove in-cell pathogens, provides new ideas and clues for the in-depth analysis of the basic cell biology problems of cell vesicle formation and regulation, and the related physiological pathological effects, and is also of practical significance for the development of new disease treatment strategies and drugs.
intracellular infection pathogens such as bacteria and viruses can use a variety of strategies to adapt and change the intracellular environment of host cells to escape the host's immune defenses.
many intracellular pathogens infect cells by using the physiological endo-swallowing vesicles of cells and adapt to the acidified environment of intracellular vesicles in order to achieve the purpose of infection.
Exogenic chemicals such as ammonium chloride and chloroquine can inhibit the infection of certain viruses and intracellular parasites by altering the acidified environment of the vesicles in the cells, but whether the host cells have corresponding defense strategies, the identity of endo-effect molecular machines and the regulatory network have been important issues that people have been trying to explore.
the first new pore-forming protein and trite factor complex betagamma-CAT (invention patent ZL200810058028. 5), it was found that the endogenous protein machine has the characteristics of stimulating cell cystic formation, forming membrane channels in the intracellular swallowing/lysosome pathway and activating inflammatory small bodies (PNAS 2014, 111, 6702, cover story).
researchers, including Li Sheng'an and Liu Long, further revealed that the protein and trite factor complex betagamma-CAT has the function of regulating the acidification environment of vesicles in cells.
In host immune defense, studies modeled on listera monocytogenes, an intracellular pathogen, have shown that the protein machine can limit listeria's escape from intracellular vesicles and stimulate extracellular excrement to expel intracellular infection pathogens, effectively protecting against the deadly listeria infection.
Sheng'an, an associate researcher at Kunming Animal Institute, and Liu Long, a doctoral student, are the first authors of the article, and Zhang Yun, a researcher, is the author of the article.
the study was supported by the key projects of the National Fund Committee-Yunnan Joint Fund and the Yunling Scholars.
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