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    Home > Biochemistry News > Plant Extracts News > Biological activity of chlorogenic acid

    Biological activity of chlorogenic acid

    • Last Update: 2020-04-03
    • Source: Internet
    • Author: User
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    Last revision: 2013-03-12 02:32 classification: efficacy 0 people commented that chlorogenic acid is composed of caffeic acid and quinic acid

    It is also known as 3-caffeoylquinic acid

    Its chemical name is 3-o-caffeoylquinic acid

    It is a phenylpropanoid compound produced by plants through the mangrove acid pathway during aerobic respiration

    Hyaluronidase (HAase) is one of the enzymes that cleave mucopolysaccharide

    It can catalyze the breakdown of hyaluronidase (HA), which is related to the permeability and inflammation of vascular system

    Ha is a kind of mucopolysaccharide composed of glucuronic acid and acetylglucosamine

    It has many functions, such as healing wounds, moistening skin, lubricating joints and preventing inflammation

    Therefore, a variety of active ingredients which can inhibit the activation of naase were found in the natural products, but also have strong anti allergic activity

    It is expected to be used as a leading compound for further development of new anti allergic drugs

    It was found that 3,5-dicaffeoylquinic acid (DCQA) and chlorogenic acid (IC50 of 1-85 and 2-25mmol / L, respectively) had a strong inhibitory effect on the activation of naase

    Glucose-6-phosphatase system (g1-6-pase) plays an important role in the regulation of blood glucose homeostasis

    It is responsible for the formation of endogenous glucose from gluconeogenesis and glycogenolysis

    Recently, chlorogenic acid has been identified as the first novel specific inhibitor of glucose-6-phosphotransferase (g1-6-p-trnaslocase) in rat liver microsomes

    By measuring the degree of g1-6-p hydrolysis in normal rat liver microsomes, the inhibitory intensity of chlorogenic acid and its synthetic analogues on the activity of displacement enzyme was determined

    Studies at home and abroad have shown that chlorogenic acid is an effective phenolic antioxidant, and its antioxidant capacity is better than caffeic acid, p-hydroxybenzoic acid, ferulic acid and Syringate, as well as common antioxidants, such as butylhydroxyanisole (BHA) and tocopherol, but it is equivalent to butylhydrotoluene (BHT)

    1-3 scavenging free radical chlorogenic acid and its derivatives have stronger scavenging effect than ascorbic acid, caffeic acid and tocopherol

    It can effectively scavenge DPPH free radical (1,1-diphenyl-2-picrylhydrazy1), hydroxyl free radical and superoxide anion free radical

    It can also inhibit the oxidation of LDL

    Chlorogenic acid can effectively eliminate free radicals in the body, maintain the normal structure and function of cells, prevent and delay the occurrence of tumor, mutation and aging

    Chlorogenic acid has a strong ability to inhibit mutation, it can inhibit the mutation caused by aflatoxin Bi and the mutation caused by sub digestive reaction, and can effectively reduce the mutation of bone marrow erythrocytes caused by y-ray; at the same time, chlorogenic acid can also achieve the effect of cancer prevention and anti-cancer by reducing the utilization rate of carcinogens and their transport in the liver

    It can also inhibit cancer caused by benzopyrene and 4-nqo (nitroquinoline oxide)

    Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer

    It is considered to be an effective chemical preservative J for cancer

    Lou Hongxiang, et al

    Obtained chlorogenic acid tetraacetylation from the water-soluble part of honeysuckle after acetylation

    The pharmacological experiment showed that it had obvious protective effect on the liver injury of mice caused by carbon tetrachloride, which provided a theoretical basis for clarifying the effect of honeysuckle on protecting liver and promoting gall

    Lijisu also has the effect of cholagogue and liver protection

    Isochlorogenic acid B can promote the release of prostacyclin (PGI2) and inhibit platelet aggregation in rats, and the inhibition rate of SRS-A release induced by antibody induced by pulmonary debris in guinea pigs is 62-3

    In addition, it has a strong inhibitory effect on thromboxane biosynthesis and hydroperoxides induced endothelial cell injury

    It has been reported that chlorogenic acid and isochlorogenic acid have strong inhibition and killing effects on a variety of pathogens and viruses

    It has obvious curative effect on acute pharyngeal inflammation and dermatosis, and is used in the treatment of acute bacterial infection

    Caffeic acid, the hydrolysate of chlorogenic acid, also has the functions of whitening, hemostasis, cholestasis and herpes simplex virus inhibition

    Recently, it was reported that Professor EICH of Free University in Germany, when studying some plant secondary metabolites as antiretroviral agents, thought that chlorogenic acid is a promising lead compound against Aizai virus (H1V)

    This is consistent with the conclusion that the basic extract of eucommia bark or leaves is effective in the treatment and prevention of HIV infection.
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