echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > Biological Psychiatr: Imbalanced temporal proportion of different brain states is a marker of cSVD-related cognitive decline

    Biological Psychiatr: Imbalanced temporal proportion of different brain states is a marker of cSVD-related cognitive decline

    • Last Update: 2022-05-23
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Clinical manifestations of cerebral small vessel disease (cSVD) include stroke, depression, and cognitive impairment


    Clinical manifestations of cerebral small vessel disease (cSVD) include stroke, depression, and cognitive impairment


    Dynamic functional connectivity (dFC) studies have revealed spatiotemporal organization that cannot be assessed with static functional connectivity methods, including brain states with multiple, temporally isolated, synchronized brain activity patterns


    Eckhard Schlemm MBBS et al.


    This study quantified cSVD by white matter hyperintensity (WMH) and skeletonized mean diffusivity peak width (PSMD)


    This study quantified cSVD by white matter hyperintensity (WMH) and skeletonized mean diffusivity peak width (PSMD)


     The study analyzed data from 979 participants (aged 45-74 years, median WMH volume 0.


    Relationship between white matter lesion volume and occupancy fraction (FO)/mean dwell time (DT)

    Relationship between white matter lesion volume and occupancy fraction (FO)/mean dwell time (DT)
    • Clustering identified five brain states with the most time spent in the activated (+) or inhibited (-) states of the default mode network (occupancy ratios: DMN+ 25.


      The study found that increased WMH burden was associated with decreased time in high-occupancy brain states and increased time in low- occupancy brain states


      This study presents for the first time the characterization of brain-wide spatiotemporal co-activation patterns present in cSVD and their correlation with associated cognitive deficits


      original source

      Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease, Biological Psychiatry, 2022, ISSN 0006-3223, https://doi.


      Equalization of brain state occupancy accompanies cognitive impairment in cerebral small vessel disease, Biological Psychiatry, 2022, ISSN 0006-3223, https://doi.
      org/10.
      1016/j.
      biopsych.
      2022.
      03.
      019.


      Leave a comment here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.