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To improve our understanding of the underlying mechanisms of NAFLD egenesis, Dr. Nina Graffmann, Professor James Adjaye, and a team from the Institute of Stem Cell Research and Regenerative Medicine at Dusseldorf University Hospital extracted hepatocellular samples (HLC) from healthy patients with a healthy supply and NAFLD, and differentiated induced pluripotent stem cells (iPSCs).
stimulation of HLC with fatty acids can mimic excessive fat intake in an individual's diet.
a recent article in the journal Biology Open attests to the strong heterogeneity of cell line in terms of gene expression and lipid drop form.
believe this is due to excessive metabolic networks during the development of the disease.
, as the team showed in earlier studies, it also reflects the many aspects that make NAFLD a highly complex disease, dependent on patient esopes (Wruck, 2015).
, scientists can still identify patterns of gene expression associated with the severity of the disease.
is a molecule synthesized by human fat cells and has been shown to have a positive effect on liver cell metabolism.
Professor Constantin Czekelius and his team produced a synthetic similar to AdipoRon for the study at the Institute of Organic Chemistry and Polymer Chemistry at Heinrich-Heine University in Dusseldorf.
AdipoRon has been first used in mice and has been shown to have significant anti-diabetic effects (Okada-Iwabu, etc., 2013).
studies have shown that AdipoRon's treatment of HLC once again leads to cell line/genetic background specificity.
, AdipoRon affects transcription of genes associated with metabolism, transport, immune system, cellular stress and signal transduction.
"We can use stem cell-based cell culture models to summarize important aspects of NAFLD."
we will use it for further research because established animal models cannot replicate complex human metabolic pathways associated with disease development.
To prove once again that although iPSC-derived hepatocellular-like cells are inherently immature, they are still of great practicality in their use in drug discovery and anatomical disease mechanisms such as NAFLD, " says Professor James Adjaye.
source: A stem cell base cell culture model for nonalcoholic fatty liver disease Source: Nina Graffman et al. A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference. Biology Open. 2020: bio.biologists.org/content/bio ... /bio.054189.full.pdf