-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
iNature
Tumor microenvironments (TME) play a vital role in the growth and metastasis of tumor tissue, and the regulation of TME provides a promising approach
for the treatment of malignant tumors.
However, developing appropriate strategies to effectively control TME remains a challenge
.
On October 14, 2022, Chen Xin and Zhang Yanmin of Xi'an Jiaotong University jointly published a paper entitled "Enhanced manipulation of tumor microenvironments by nanomotor for synergistic therapy of malignant tumor" online in Biomaterials (IF=15).
", which developed a nanomotor to enhance control of the tumor microenvironment for synergistic treatment
of malignant tumors.
The study prepared a Ce6@A T-PEG-MSN-PT (CAPMP) nanomotor that can move spontaneously in tumor tissue while performing enhanced manipulation of various tumor microenvironments, including copper levels, hypoxia, local temperature, and reactive oxygen species (ROS), to enable effective tumor treatment
.
CAPMP nanomotors are composed of platinum-mesoporous silica cores with acylthiourea groups (copper chelate) conjugated polyethylene glycol on the surface and chlorinated e6 (photosensitizer)
in the pores.
During treatment, the acylthiourea group on CAPMP traps overexpressed copper in tumor tissue and tumor cells, resulting in severe copper
deficiency in tumors.
Chlorinated e6 is responsible for the generation of ROS (1O2) in tumors through a photodynamic process, and irradiation at 660 nm can trigger ROS
(1O2).
The platinum layer of CAPMP is both a photothermal agent and anO2-generating agent
.
The local temperature is rapidly increased under irradiation at 808 nm, while the overexpressedH2O2is converted toO2
in tumor tissue by catalytic reaction.
The production of O2 not only drives the continuous movement of CAPMP and improves its efficiency of copper capture, but also reverses the hypoxic environment in large areas and deep parts of tumor tissue, and further promotes the production of 1O2 performance
of CAPMP.
Both in vitro and in vivo experiments have shown that the increase of local temperature and the increase of 1O2 concentration have obvious damage to tumor tissue, which is conducive to the elimination of primary tumors, while copper deficiency and hypoxia reversal further hinder the migration and inhibition of tumor cells, which is an effective strategy
for the treatment of malignant tumors.
In addition, on February 15, 2022, Chen Xin and Zhang Yanmin of Xi'an Jiaotong University jointly published a publication in Advanced Materials (IF=32) magazine entitled " Intelligent Gold Nanoparticle swith Oncogenic MicroRNA-dependent Activities to Manipulate Tumorigenic Environments for Synergistic Tumor Therapy" In order to meet this challenge, spherical nucleic acids
with gold nanoparticles as the core and antisense oligonucleotides as the shell were prepared.
Crosslinked to the oligonucleotide shell is a doxorubicin-conjugated DNA sequence (DNA-DOX).
The oligonucleotide shell is designed to capture overexpressed miR-21/miR-155 and inhibit the expression of these oncogenic miRNAs in tumor cells after tumor accumulation to manipulate the genetic environment for accurate gene therapy
.
This process further induces the aggregation of these SNAs, which not only produces a photothermal agent, realizes in situ on-demand photothermal therapy, but also expands the size of SNAs and improves the residence time of SNAs in tumors for continuous treatment
.
The capture of relevant miRNAs simultaneously triggers the release of DNA-DOX from within the cells of SNAs to deliver tumor-specific chemotherapy
.
In conclusion, the results of this study show that this combination therapy strategy has a good tumor suppression effect and a high survival rate of tumor-bearing mice, which is expected to become an effective tumor treatment method (click to read).
Because of its high morbidity and mortality, malignant tumors are one of
the diseases that seriously threaten human health.
Although various strategies such as surgery, radiotherapy, and chemotherapy have been developed and achieved certain therapeutic effects, tissue damage and unexpected side effects of these traditional methods still limit their clinical application
.
In view of the above problems, new methods such as photothermal and photodynamic methods based on various photoresponsive nanomaterials have been introduced into tumor treatment because of their high controllability, small side effects and good efficacy
.
These strategies can control the tumor microenvironment (TME) by increasing local temperature and increasing the concentration of reactive oxygen species (ROS) in tumor tissue, thereby damaging tumor cells, providing a promising approach
for tumor treatment.
Although photothermal therapy and photodynamic therapy open a window for effective and accurate treatment of primary tumors, metastasis of the tumor during treatment remains a difficult problem, which is the most important cause of
patient death.
Therefore, the treatment of malignant tumors requires novel materials
that can control ROS and temperature while preventing tumor metastasis.
In recent years, studies have found that the abnormally high copper and hypoxic environment in tumors play a crucial role in tumor metastasis, in which excess copper stimulates various metastasis-related progresses such as proliferation and migration of tumor cells, while hypoxia triggers the invasion and internal invasion
of tumor cells.
Therefore, simultaneous regulation of intratumor copper concentration, hypoxic environment, ROS level and local temperature is an ideal way to
eliminate the primary tumor and inhibit tumor metastasis.
Although copper poisoning based on various copper-doped nanomaterials is also an effective strategy for manipulating copper in tumor cells and has a significant inhibitory effect on tumor tissues, excessive copper poisoning may damage surrounding healthy tissues because copper poisoning requires a certain amount of copper to at least exceed the tolerance capacity of tumor cells, and the natural copper levers in tumor cells are much higher than normal cells
.
Therefore, copper deficiency to inhibit tumors will be a safer and effective tumor treatment
.
While various copper eliminators and oxygen-generating agents such as hemoglobin, calcium peroxide and manganese dioxide have been developed to achieve anti-transfer, an all-in-one device with optimal synergy remains a challenge
.
In addition, the performance of copper removal and hypoxia mitigation is highly dependent on the distribution of copper eliminators and oxygen producers, as well as collisions between copper and copper eliminators, which are driven
by free diffusion in current methods.
This weak movement limits their therapeutic range, depth, and efficiency, resulting in inadequate
ability to inhibit tumor metastasis.
Ce6@A Schematic diagram of the synthesis and treatment mechanism of TPEG-MSN-Pt (CAPMP) nanomotor (Figure from Biomaterials) In order to achieve efficient simultaneous regulation of copper concentration, hypoxic environment, ROS level and local temperature in tumors, acylthiourea (AT, copper chelating agent) loaded with e6 chloride (photosensitizer Ce6) was prepared.
Janus platinum-mesoporous silica nanoparticles (MSN-Pt, photothermal agent,O2 generator and nanomotor) co-modified with polyethylene glycol (Ce6@A T-PEG-MSN-PT, abbreviated as CAPMP) contribute to the comprehensive elimination of primary tumors and metastasis inhibition for better treatment of tumors
.
After intratumoral injection, the CAPMP nanomotor first converts the abundantH2O2in tumor tissues/cells intoO2 due to the catalytic action of platinum, which not only drives CAPMP to penetrate tumor tissues/cells, but also effectively alleviates the hypoxic microenvironment
in a wide range and deep part of tumor tissues.
During the continuous movement of CAPMP, chelation between acylthiourea and copper also occurs constantly, enhancing copper pillage
.
The resulting tumor oxygen enrichment and copper deficiency inhibit the migration of tumor cells, thereby inhibiting tumor metastasis
.
CAPMP is widely distributed, efficiently transporting chloroprotein e6 and platinum deep into
the tumor.
Due to the good photodynamic properties of the chlorinated e6 and platinum layers, and the promotion of photodynamic processes induced by platinum-induced oxygen-enriched microenvironment, the distributed chloride ion e6 and platinum significantly increased the ROS (1O2) level and temperature of the entire tumor under irradiation at 660 nm and 808 nm, which is expected to completely damage the primary tumor
.
Original link: —END—the content is 【 iNature】
