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    Home > Active Ingredient News > Infection > bioRxiv: The decisive factor for the new crown host has been identified?

    bioRxiv: The decisive factor for the new crown host has been identified?

    • Last Update: 2022-05-16
    • Source: Internet
    • Author: User
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    On April 7, 2022, the biomedical preprint bioRxiv was published online jointly by the University of Lyon, France, the University of California, Los Angeles, the French Institute for Genetic Reproduction and Development, the European Center for Viral Bioinformatics in Germany, and the French Institute of Bioinformatics.


    On April 7, 2022, the biomedical preprint bioRxiv was published online jointly by the University of Lyon, France, the University of California, Los Angeles, the French Institute for Genetic Reproduction and Development, the European Center for Viral Bioinformatics in Germany, and the French Institute of Bioinformatics.


    Let's talk about the main point first

    Let's talk about the main point first let's talk about the main point

    It is well known that viruses and hosts are constantly evolving in the process of interaction.


    It is well known that viruses and hosts are constantly evolving in the process of interaction.


    As a result, researchers performed a high-throughput evolutionary analysis of 334 SARS-CoV-2 interacting proteins to identify SARS-CoV adaptive sites and reveal functional differences between modern humans, primates, and bats, and further Uncover how the past shaped modern virus reservoirs and humans during this interactive evolution


    Through this relationship, the researchers further identified 81 primates and 38 bat VIPs with adaptive evolutionary traits


    Next, the researchers delineated an adaptive interactome centered around the commonalities between the above species, showing host-specific determinants associated with different host lineages in different evolutionary trajectories


    The researchers found evidence for the primate-specific adaptive entry factor TMPRSS2, suggesting its importance in the host and predicting the virus-host molecular interface from this factor


    Literature Analysis Literature Analysis

    The COVID-19 pandemic was caused by SARS-CoV-2, a novel coronavirus that spilled over from bat virus reservoirs (current evidence suggests)


    The COVID-19 pandemic was caused by SARS-CoV-2, a novel coronavirus that spilled over from bat virus reservoirs (current evidence suggests)


    Notably, residues involved in the ubiquitination and phosphorylation of inflammatory RIPK1 evolved rapidly in bats but not in primates, suggesting that inflammatory regulation in bats differs from that in humans


    Notably, residues involved in the ubiquitination and phosphorylation of inflammatory RIPK1 evolved rapidly in bats but not in primates, suggesting that inflammatory regulation in bats differs from that in humans


    Characterization of the evolutionary history of SARS-CoV-2 VIP in bats and primates Characterization of the evolutionary history of SARS-CoV-2 VIP in bats and primates

    Past epidemics have resulted in the accumulation of adaptive traits in VIP genes as pathogenic viruses and hosts engage in an evolutionary arms race


    Past epidemics have resulted in the accumulation of adaptive traits in VIP genes as pathogenic viruses and hosts engage in an evolutionary arms race


    Identification and comparative analysis of SARS-CoV-2 VIPs characterized by positive selection during bat and primate evolution Identification and comparative analysis of SARS-CoV-2 VIPs characterized by positive selection during bat and primate evolution

    Researchers have found a trend similar to positive selection in natural selection of bat and primate genes


    Researchers have found a trend similar to positive selection in natural selection of bat and primate genes


    SARS-CoV-2 prediction interface in TMPRSS2 evolved under adaptive evolution in primates but not in bats

    The SARS-CoV-2 prediction interface in TMPRSS2 evolved under adaptive evolution in primates, but not in bats The SARS-CoV-2 prediction interface in TMPRSS2 evolved under adaptive evolution in primates, but no in bats

    Guided by evolutionary analysis, researchers conducted mutagenesis studies on TMPRSS2 to determine the determinants associated with SARS-CoV and the functional implications of interspecies variation in MPRSS2
    .
    The results suggest that positive selection traits in TMPRSS2 are closely related to SARS-CoV-driven selection pressures during primate evolution
    .
    The above phenomenon has not been found in bats
    .

    Guided by evolutionary analysis, researchers conducted mutagenesis studies on TMPRSS2 to determine the determinants associated with SARS-CoV and the functional implications of interspecies variation in MPRSS2
    .
    The results suggest that positive selection traits in TMPRSS2 are closely related to SARS-CoV-driven selection pressures during primate evolution
    .
    The above phenomenon has not been found in bats
    .

    Evidence for the involvement of FYCO1 in SARS-CoV pathogenesis or replication at different timescales during primate evolution

    Evidence for the involvement of FYCO1 in SARS-CoV pathogenesis or replication at different timescales during primate evolution Evidence for FYCO1 involvement in SARS-CoV pathogenesis or replication at different timescales during primate evolution

    FYCO1 is involved in microtubule trafficking and autophagy
    .
    However, FYCO1 is one of the very few genes found to be significantly associated with severe COVID-19 in human genome-wide association studies (GWAS)
    .
    Indicate the importance of FYCO1 in SARS coronavirus pathogenesis or replication in primates
    .

    FYCO1 is involved in microtubule trafficking and autophagy
    .
    However, FYCO1 is one of the very few genes found to be significantly associated with severe COVID-19 in human genome-wide association studies (GWAS)
    .
    Indicate the importance of FYCO1 in SARS coronavirus pathogenesis or replication in primates
    .

    RIPK1 has been undergoing adaptive evolution in bats at residues critical for human regulation

    RIPK1 has been adaptively evolving in bats at residues critical for human regulation in RIPK1

    Human RIPK1 is an adaptor protein involved in inflammation through tumor necrosis factor alpha receptor 1 (TNFR1) and Toll-like receptors 3 and 4 (TLR3/4), resulting in pro-survival, apoptotic or necroptotic signaling
    .
    Careful analysis of RIPK1 interactors revealed that it is a central hub for 79 cellular partners involved in key inflammatory and cell survival/death processes
    .
    RIPK1 interacts with SARS-CoV-2 NSP12 (RdRp) and is further involved in a variety of bacterial and viral infections
    .

    Human RIPK1 is an adaptor protein involved in inflammation through tumor necrosis factor alpha receptor 1 (TNFR1) and Toll-like receptors 3 and 4 (TLR3/4), resulting in pro-survival, apoptotic or necroptotic signaling
    .
    Careful analysis of RIPK1 interactors revealed that it is a central hub for 79 cellular partners involved in key inflammatory and cell survival/death processes
    .
    RIPK1 interacts with SARS-CoV-2 NSP12 (RdRp) and is further involved in a variety of bacterial and viral infections
    .

    Summarize

    summary summary

    At the heart of studies analyzing the SARS-CoV-2 VIP coding sequence is the identification of multiple SARS-CoV-2 interacting protein sites, which may reflect the exact site of the viral and antiviral molecular arms race
    .
    Therefore, these sites are critical for SARS-CoV-2 host determinants
    .
    Furthermore, VIPs represent an important host-pathogen interface
    .
    Therefore, the development of antidrugs targeting strong viral host arms race hallmarks may be an effective broad-based antiviral strategy
    .

    At the heart of studies analyzing the SARS-CoV-2 VIP coding sequence is the identification of multiple SARS-CoV-2 interacting protein sites, which may reflect the exact site of the viral and antiviral molecular arms race
    .
    Therefore, these sites are critical for SARS-CoV-2 host determinants
    .
    Furthermore, VIPs represent an important host-pathogen interface
    .
    Therefore, the development of antidrugs targeting strong viral host arms race hallmarks may be an effective broad-based antiviral strategy
    .

    Original source:

    Original Source: Original Source:

    Marie Cariou, Léa Picard, Laurent Guéguen, et al.
    Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19 .
    bioRxiv, 2022.

    Marie Cariou, Léa Picard, Laurent Guéguen, et al.
    Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19 .
    bioRxiv, 2022.
    Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

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