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Bispecific antibody epcoritamab yields positive results in LBCL, including in patients who have failed CAR-T cell therapy

 Last Update: 2022-05-21
 Source: Internet
 Author: User

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Biopharmaceutical companies AbbVie and Genmab today announced updated results from a Phase I/II trial evaluating the bispecific antibody epcoritamab in patients with relapsed/refractory large B-cell lymphoma (LBCL).

Lymphoma CAR-T

The EPCORE NHL-1 trial is designed to evaluate epcoritamab in patients with relapsed, advanced or refractory CD20 ⁺ mature B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL)

⁺Nearly 40% of whom received prior CAR-T cell therapy Nearly 40% of whom received prior CAR-T cell therapy AbbVie and Genmab said the ORR for this cohort was 63.

The most common grade 3 or 4 treatment-related adverse events included neutropenia, anemia, and thrombocytopenia

When the two companies formed a partnership in 2020 to develop next-generation bispecific antibodies, including epcoritamab, AbbVie paid Genmab $750 million upfront

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