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BJH: Immunogenicity and safety of BNT162b2 mRNA COVID-19 vaccine in recipients of hematopoietic stem cell transplantation

 Last Update: 2021-11-13
 Source: Internet
 Author: User

Immunogenicity of BNT162b2 after vaccination

At a median time of 28 days (IQR 8-69) after the second vaccination, 118 patients (77·6%) developed RBD IgG with a GMT of 2.

P P

Multivariate logistic regression model of RBD IgG positivity between HSCT recipients and immune normal controls (n= 424)

CI, confidence interval; HSCT, hematopoietic stem cell transplantation; IgG, immunoglobulin G; RBD, receptor binding domain

IgG quantification after the second vaccination of BNT162b2 vaccine in HSCT recipients and immunocompetent medical staff controls

The study found that there is a high correlation between RBD binding IgG and NA, r= 0·70 (95% CI 0·59, 0·78; P<0·0001) (Figure2 ) r P (Figure2 )

Correlation between RBD IgG and logarithmic transformed neutralizing antibodies

After the second vaccination, no patients in the cohort were infected with SARS-CoV-2, and the median follow-up time was 108 (104-114) days

In summary, the BNT162b2 mRNA vaccine is safe and effective in HSCT recipients, especially those without immunosuppression

Original source:

Shem-Tov, N.

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