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Prostate cancer is the most common cancer in Western men and the second leading cause of cancer death
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Median survival for patients with metastatic disease was 42.
1 months, and until recently the standard of care was the original androgen deprivation therapy (ADT)
Until recently, the standard of care was also the original androgen deprivation therapy (ADT) until recently, the standard of care was also the original androgen deprivation therapy (ADT) only
Recently, researchers from the United Kingdom published an article in "BJU Int" to test the randomization of radical prostatectomy plus pelvic surgery on the basis of standard of care (SOC) systemic treatment in men with newly diagnosed oligometastatic prostate cancer.
Feasibility of lymphadenectomy (RP)
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The study was a prospective, randomized, open-label, feasibility clinical trial using the QuinteT Recruitment Intervention (QRI) to optimize recruitment and was conducted in nine tertiary care centers across the country
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During an 18-month recruitment period, 50 men with oligometastatic prostate cancer were randomized to SOC systemic therapy versus SOC plus RP (intervention group)
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Quality of Life
RESULTS: Of the 176 participants, a total of 71 met the inclusion criteria, of whom 51 men were randomized (one of whom was subsequently determined to be ineligible)
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Under QRI-optimized conditions, recruitment increases were 60-83%
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PSA, function, and quality of life outcomes 3 months after randomization
PSA, function, and quality of life outcomes 3 months after randomizationIn conclusion, random surgical intervention in men with synchronous oligometastatic prostate cancer is feasible in addition to standard systemic therapy
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Although in this feasibility study the surgery appeared to be safe with no substantial impact on QOL , a large randomized controlled trial is warranted to test this multimodal management of other oligometastatic prostate cancer Treatment effects of interventions
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Randomized surgical intervention in men with synchronous oligometastatic prostate cancer is feasible in addition to standard systemic therapy
Original source:
Prasanna Sooriakumaran, Caroline Wilson, Ines Rombach et al.
Feasibility and safety of radical prostatectomy for oligo-metastatic prostate cancer: TRoMbone trial .
Feasibility and safety of radical prostatectomy for oligo-metastatic prostate cancer: TRoMbone trial Leave a Comment