Blocking nerve signals in the pancreas inhibits type 1 diabetes

a recent study published in the journal Science Advance, researchers at the La Jolla Institute for Immunology (LJI) reported that the nervous system may promote the death of pancreatic beta cells. Their new findings in mouse models suggest that blocking nerve signals in the pancreas can prevent patients from developing type 1 diabetes., LJI professor Dr Mattias von Herrath, senior author of the study, said: "This process may be halted by the influence of neurons. Thevon Herrath Laboratory has long struggled to find the cause of type 1 diabetes. Although the disease has environmental and genetic risk factors, the onset of type 1 diabetes appears to be random. For years, researchers have been looking for the cause of beta cell death. One theory is that these cell deaths stem from differences in blood supplies around them, or are damaged by immune attacks triggered by viral infections.to test this theory, the researchers used a mouse model that could artificially induce β cell death. They "weaken nerves" through surgery or using neurotoxins or pharmacological methods, blocking the sensory nerve signals of most pancreas. The researchers then used imaging devices to track the β cell deaths in mice.team found that blocking nerve signals protected mice from cell death compared to mice that were not treated and those who were given β only β-blockers. "We found significant differences in these nerve blockers in affecting the onset of diabetes."the new findings go far beyond explaining cell death in type 1 diabetes. Several autoimmune diseases are known to have similar cell deaths. For example, vitiligo and arthritis, etc.Von Herrath believes that breakthroughs in neuroimmune science could have broad implications for explaining why the body reverses its own organs in many autoimmune diseases. Looking ahead, the authors hope to study the cellular mechanisms between the nervous system and the onset of type 1 diabetes. (Bio Valley Bioon.com)Source: Blocking nerve signals to the pancreas halts type 1 diabetes onset in miceOriginal source: "The Process with pancreatic signaling halts onset of diabetes in mice" Science Advances (2020). advances.sciencemag.org/lookup . . . 1126/sciadv.abb2878