Blocking the ability of gonorrhea pathogens to absorb zinc or hopefully inhibit gonorrhoea infection and transmission!

There is no vaccine to curb this serious infectious disease, with more than 820,000 people suffering from gonorrhea each year in the United States, and more than half of all cases are among young people aged 15-24, and Neisseria gonorrhoeae is a gonorrhea pathogen that is considered one of the current threats to public health because it is resistant to almost all therapeutic drugs and is difficult to cureuntreated gonorrhea often causes serious or permanent health problems, and most women do not show symptoms, in the female population, gonorrhea can cause pelvic inflammatory diseases, which often lead to infertility and ectopic pregnancy and other diseasesResearcher Cynthia Nau Cornelissen said the results of the study are important because gonorrhea Neisseria can die if not enough zinc is availablegonorrhea Neisseria produces eight known membrane transport proteins, four of which can be used to obtain iron or iron chelates, and two transporting proteins TdfH and TdfJ promote cell-to-zinc intakeIn previous studies, researchers found that TdfH was able to bind to calcium protein, a member of the S100 protein family, and then be absorbed by gonorrhea NeisseriaIn the study, researchers assessed whether other proteins in the S100 family could also promote the growth of Neisseria by ingesting zinc, and found that TdfJ binds directly to S100A7 to obtain zinc;results show that nephrorised nesayoridal bacteria may be able to "defeat" the nutritional immunity of the human body through the interaction between TdfJ and human S100A7, thus promoting pathogens to overcome host restrictions on zinc and continue to growThe researchers hope to protect the body from the infection of neestonenesis nayshed in take on zinc ions or by potentially helping to develop new vaccines against the pathogen, with the goal of developing a new vaccine to block the intake of nissa neestogoalysis into iron and zincOrigins: Stavros Maurakis, Kayla Keller, CNoel Maxwell, et alThe Cosmo SInteraction Neisseria Gonorrhoeae TdfJ and Human S100A77 Gonococci to Subvert Host Zinc Restriction, PLoSS S (2019)DOI: 10.1371/journal.ppat.1007937original title: PLoS Pathog: Blocking the intake of key minerals is expected to effectively inhibit the infection and spread of gonorrhea!