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Primary oozed lymphoma (PEL) is an invasive malignant tumor with poor prognosis even in the case of active chemotherapy, usually accompanied by Kaposi sarcoma-associated herpes virus (Kaposi's sarcoma-associated herpesvirus, KSHV) infection, one of the human cancer-causing virusesAt present, THERE IS NO SPECIFIC TREATMENT FOR PEL, SO IT IS IMPORTANT TO DEVELOP NEW TREATMENTSLipid metabolism plays an important role in determining the fate of tumor cellsPrevious studies have shown that phospholipid metabolism is associated with the survival of KSHV plus tumor cellsIn order to further develop the targeted treatment of phospholipid metabolism, after screening a series of newly synthesized neuroamide analogues, Chen et alscreened out compounds with effective anti-PEL activityThese compounds induce the production of PEL apoptosis, cell cycle block and intracellular ceramide by regulating ceramide synthesis or ceramide metabolism enzymes, and significantly inhibit tumor progression in the body without significant toxicityThese new compounds also increase the expression of the virus lysate gene in PEL cellsIn addition, transcription alcdc analysis also revealed the mechanism of these compounds to induce pel cell death, and identified a new set of cell genes, including AURKA and CDCA3, subject to the regulation of lipid metabolism, is essential for PEL survivalThese data provide a framework for the development of targeted drugs based on phospholipid metabolism in this viral-related malignant tumor