Blood: A small number of T-cells that identify tumor-related antigens stimulate antitumor response
Last Update: 2020-06-16
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Tumor-related antigen (TAA) is a monomorphic self-antigen that is considered an immunotherapy target for malignant tumorsIs it possible to find T-cells with sufficient affinity in the T-cell pool of healthy donors to identify self-antigens that are naturally overexpressed in their own HLA context? Marthe et alare working on thisThe secondary tissue-compatible antigen (MIHA)-specific T-cells are modelled on the effects of thymus selection against MiHA's T-cell lineage that can be studied in both its own (MiHApos donor) and non-self (MiHAneg donor)Isolated from HA-1H neg /HLA-A?02:01 pos and HA-1H pos/HLA-A-02: 01 pos donor to target HLA?02: 01 restrictive MiHA HA-1H T-cell cloningOf the 16 HA-1H-specific T-cell clones, 5 were from HA-1H neg/HLA-A-02: 01 pos donors and 1 T-cell clone from HA-1H pos/HLA-A-02: 01 pos donor T-cell cloning showed resistance to ha-1H pos target cellsIn addition, 663 T-cell clones targeting TAA WT1-RMF, RHAMM-ILs, Proteinase-3-VLQ, PRAME-VLD and NY-ESO-1-SLL are isolated from HLA-A-02: 01 pos donors (including at least 91 unique clones of different T-cells expressedOnly 3 PRAME-VLD and 1 NY-ESO-1-SLL-specific T-cell cloning are naturally overexpressed by HLA-A-02: 01 pos malignant cell line (not the original malignant specimen) and can induce ifN-iso-iso-production and/or cell dissolutionThese results show that there are self-contained HLA restrictive T cells in the peripheral blood of healthy people for their own antigens, such as MiHA and TAA in MiHA pos donors, but clinical efficacy needs to be effectively immunized in the body by peptide vaccine in the case of appropriate adjulics, or in vitro amplification of a small number of autogen-specific T-cells have sufficient affinity to identify endogenous processing antigens
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