Blood Adv: A new human organ chip has been used to reveal the molecular mechanisms by which ovarian cancer metastasis occurs by the power of plateplates.

17, 2020 // -- In a recent study published in the international journal Blod Advances, scientists from Texas Agricultural University and others revealed the interactions between ovarian cancer tumors, blood vessels, and plateplates, and found that ovarian cancer may break the blood vessel barrier so that it can communicate with blood cells such as plate plate plates, which begin to metascess or spread to other parts of the body.
Photo Source: Currently, researchers at Texas A and M Engineering believe plateplates or ovarian cancer metastasis agents, but they don't know exactly what mechanisms can introduce plateboards into tumor cells, compared to the very difficult study of the mysteries in animal models, in which researchers propose a new solution, the organ chip study.
human organ chip is a USB drive-sized particle medical device that researchers designed on the OvCa chip to make it easier to observe the interaction between tumors and plateplates.
researcher Jain explains that a particular micro-environment promotes co-culture of ovarian tumor cells with blood vessels, which can then interact with blood cells, and then researchers can further study how drugs affect their interactions.
Looking at the interaction between tumors and blood vessels on an OvCa chip can give researchers unexpected results, noting that tumor cells systematically break down endotrine cells, a natural barrier that blocks the interaction between the external environment and blood cells arranged on the lining of blood vessels, and that once that barrier is broken, blood cells such as plate plates enter the tumor micro environment and are recruited by cancer cells to promote cancer metastasis.
The use of the results may hopefully help clinicians develop new treatments for ovarian cancer, while the researchers note that some antivascular drugs may also be used in combination with anti-cancer therapies, and that the benefit of the human organ chip is that it monitors and detects these new drug therapies and combinations of drugs, and that the chip's other use is to diagnose the disease, said researcher Ja 'We have to be clear that these chips are living chips that contain living cells, and the advantage is that they may be real human samples, so this new technology could help us develop new individualized therapies in the future so that we can extract stem cells and other cells from patients and use them to create complete chips for a single patient to study the progress of a patient's disease,' he said.
original source: Biswajit Saha, Tanmay Mathur, Katelyn F. Handley, et al. OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer, Blood Advances (2020). DOI: 10.1182/bloodadvances.2020001632.