Blood: Correlation analysis between intestinal flora and complications after hematopoietic stem cell transplantation
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Last Update: 2020-06-23
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Source: Internet
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Author: User
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To date, studies of the prognostic correlation between gastrointestinal microorganisms and allo-HCT have focused on early complications, common infections, and acute graft anti-host disease (GVHD)Using case-control research design, Marke et alstudied the potential relationship between the microbiome and chronic graft anti-host disease (cGVHD) by analyzing stool and plasma samples collected late after the transplantation of allogeneic hematopoietic stem cellsresearchers found lower levels of short-microbial-derived short-frequency fatty acids (SCFA) alcoparic acid and butyric acid in the plasma sample at the 100th day of the plasma sample compared to patients with no complications in the initial transplant patient's case control queue and in another independent transplant center queuethe researchers also analyzed another horizontal patient queue from a third transplant center, but some serum, not plasma, and the SCFA differences observed in the plasma samples were not reproducedin general, the results of case control cohorts and one of two horizontal cohort studies show that the gastrointestinal microbiome may have an immune regulatory effect on patients with allo-HCT, at least in part because of the effect of controlling the systemic concentration of short-chain fatty acids from microbial sources
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