echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Blood: Effects of DHFR and FPGS germ cell mutations on methotrexate metabolism and RISK OF ALL recurrence

    Blood: Effects of DHFR and FPGS germ cell mutations on methotrexate metabolism and RISK OF ALL recurrence

    • Last Update: 2020-06-16
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit
    Methotrexate (MTX) maintenance therapy is critical for the treatment of acute lymphoblastic leukemia (ALL), but achieving appropriate treatment doses with individual differences remains a challenge when configuring the drugTo evaluate genetic factors associated with MTX metabolism, the researchers analyzed 447 ALL cases in the "Nordic Society for Paediatric Haematology and Oncology ALL2008" study and validated it in a separate queue of 196 patientsIt was found that an intergene SNP (rs1382539) located on the original DHFR gene regulation was associated with an increase in levels of short-chain methotrexate glutamate because of its inhibitory activity, while rs35789560 (p.R466C) on FPGS was associated with reduced levels of long-chain methotrexateIn addition, FPGS variation is also associated with an increased risk of ALL recurrenceIn summary, the results of this study reveal the genetic basis of differences in response to methotrexate treatment in ALL patients, or may help improve future drug administration algorithms
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.