Blood: Factors related to the prognosis of new coronavirus infection in patients with multiple myeloma

The main cause of morbidity and death in patients with multiple myeloma (MM) is infection.
therefore, during the COVID-19 pandemic, great attention was paid to the prognostics of MM patients infected with COVID-19.
retrospective study summarized baseline characteristics and clinical prognostics in 650 patients infected with COVID-19 plasma cell disease.
the average age of mortality patients in different countries was 69 years, almost all (96%) were MM.
about 36 per cent of patients were diagnosed in the last two years (2019-2020) and 54 per cent had received first-line treatment.
33 per cent of patients had died, with significant geographical differences, with mortality rates fluctuating between 27-57 per cent among inpatients across regions.
analysis of risk factors associated with death found age, ISS3, high-risk diseases, kidney disease and poorly controlled myeloma (active or progressive) and one or more combinations as risk factors for high mortality.
bone marrow transplants, even in COVID-19 infections, had no significant correlation with prognostics;
multivariable analysis found that only age, high-risk MM, kidney disease and MM poor control are still independent predictors of poor prognosis of COVID-19 infection.
In summary, during the COVID-19 pandemic, MM patient management needs to carefully consider patient and disease-related factors to reduce the risk of COVID-19 infection, while treating MM patients infected with COVID-19, it is necessary to take due care of both diseases.
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