Blood: New risk scoring method for predicting event-free survival rates after allo-HCT in patients with sickle cell disease
Last Update: 2020-06-16
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Ruta et aldeveloped a risk score to predict the event-free survival rate (EFS; probability of implantation in a donor) after transplantation of allogeneic hematopoietic cells in patients with sickle cell diseaseThe study population (n-1425) was randomly divided into training groups (n-1070) and validation groups (n-355)Build a Cox regression model to identify and validate risk factorsOf the nine risk factors assessed, two biological risk factors had a predictive effect on EFS: age at transplant time and donor typeBased on the training queue, patients with hlA-matched siblings who were donors with an age of 12 had the lowest risk, with a 3-year survival rate of 92% (95% CI 89-94) and a score of 0Siblings with an AGE of 13 and HLA matching are donors or non-relative donors with HLA matching are at medium risk (score s 1; 3 years EFS 87%, 95% CI 82-91)The remaining groups, including patients of any age age, had monoploid relatives or non-relative donors with A mismatch in HLA, and patients with non-kinship donors with HLA matching age of 13 years and HLA matching were all high-risk patients (rating s 2 or 3; 3 years EFS 57%, 95% CI 50 to 64)These findings are confirmed in the validation queueThis simple risk score may help guide clinicians and sickle cell patients in choosing the most appropriate transplant treatment
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