echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Blood: New risk scoring method for predicting event-free survival rates after allo-HCT in patients with sickle cell disease

    Blood: New risk scoring method for predicting event-free survival rates after allo-HCT in patients with sickle cell disease

    • Last Update: 2020-06-16
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit
    Ruta et aldeveloped a risk score to predict the event-free survival rate (EFS; probability of implantation in a donor) after transplantation of allogeneic hematopoietic cells in patients with sickle cell diseaseThe study population (n-1425) was randomly divided into training groups (n-1070) and validation groups (n-355)Build a Cox regression model to identify and validate risk factorsOf the nine risk factors assessed, two biological risk factors had a predictive effect on EFS: age at transplant time and donor typeBased on the training queue, patients with hlA-matched siblings who were donors with an age of 12 had the lowest risk, with a 3-year survival rate of 92% (95% CI 89-94) and a score of 0Siblings with an AGE of 13 and HLA matching are donors or non-relative donors with HLA matching are at medium risk (score s 1; 3 years EFS 87%, 95% CI 82-91)The remaining groups, including patients of any age age, had monoploid relatives or non-relative donors with A mismatch in HLA, and patients with non-kinship donors with HLA matching age of 13 years and HLA matching were all high-risk patients (rating s 2 or 3; 3 years EFS 57%, 95% CI 50 to 64)These findings are confirmed in the validation queueThis simple risk score may help guide clinicians and sickle cell patients in choosing the most appropriate transplant treatment
    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.