echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Blood of China University of Science and Technology: Mechanism of early recurrence of AML after allo-HSCT

    Blood of China University of Science and Technology: Mechanism of early recurrence of AML after allo-HSCT

    • Last Update: 2022-09-09
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    A few days ago, the research group of Professor Wei Haiming from the Department of Life Sciences and Medicine of the Chinese University of Science and Technology cooperated with the team of Professor Sun Zimin and Professor Zhu Xiaoyu from the Department of Hematology of the First Affiliated Hospital to investigate the relapse mechanism and intervention of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).


    AML is the most common acute leukemia in adults and has a poor prognosis


    The immune escape mechanism of tumor cells has always been a major issue of international concern


    In order to prove the activation mechanism of TGF-β1, the researchers systematically analyzed the changes in the expression of GARP molecules, and proved that GARP is highly expressed on the surface of CD4+ T cells in the bone marrow of relapsed patients


    In order to explore whether inhibiting the TGF-β1 signaling pathway can restore the anti-tumor function of bone marrow NK cells, the researchers added TGF-β1 neutralizing antibodies and TGF-β1/TGF-βR1 signal blockers to the bone marrow NK cells of relapsed patients.


    CD4+ T cells activate TGF-β1 via GARP and mediate myeloid NK cell inactivation

    In conclusion, this study found that CD4+ T cells in the tumor microenvironment of AML patients after allo-HSCT inhibited the anti-tumor function of bone marrow NK cells by activating TGF-β1, resulting in leukemia relapse


    Professor Wei Haiming, Professor Sun Zimin and Professor Zhu Xiaoyu are the co-corresponding authors of the paper


    The research work has been supported by the Chinese Academy of Sciences, the National Natural Science Foundation of China, the "New Medicine of the University of Science and Technology" and the China Postdoctoral Science Foundation


    Article link: https://ashpublications.



    (Department of Life Science and Medicine, First Affiliated Hospital, Research Department)


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.