Blood: Small intestine organs successfully reproduce susceptibility to T-cell-mediated tissue damage

One of the goals of precision medicine is to use the materials provided by patients to predict disease processes and outcomesin this study,Ishimoto et aldesigned an in vitro platform using mechanical observations in preclinical animal models to reconstruct the genetic susceptibility to T-cell-mediated damageintestinal graft anti-host disease (GVHD) is a life-threatening complication of allo-HCT transplantationIshimoto et alfound that in mice with atg16L1 (a polymorphic autophagy gene) defect, the intestinal GVHD can be reversed by inhibiting necrosis, the researchers also found that the heterogeneous T-cells co-cultured small intestine organs that can kill the Atg16L1 mutation from mouse sources, which is associated with abnormal epithelial interferon signalsused this information, the researchers demonstrated that transduction from drug-suppressing necrosis or interferon signals could protect organs from xenogene T-cells from humans carrying the common ATG16L1 mutation, this study provides a new way of thinking about the application of research on animal models to individualized treatments for affected tissues