BMC Cancer: Association of Breast Cancer and Intestinal Microbiome Disorders with Breast Cancer Risk

Breast cancer ranks first among women and the second leading cause of death in this sexIn addition to genetic factors, the environment is one of the causes of the disease, although the factors are not clearIn the latter, the effects of microorganisms are one of them, so recent attention has been paid to the breast microbiomeWe speculate that the risk of breast cancer may be related to the composition and function of the breast/intestinal microbiome, which may be altered by exposure to environmental pollutants (endocrine disruptors, EDCs)
We describe a case-control clinical study in women between the ages of 25 and 70The cases will be women diagnosed with breast cancer (Stage Ii) and undergoing surgical interventionsWomen who have received antibiotic treatment or any new complementary treatment during the pre-cancer or advanced stage of cancer (metastasis), or who have received antibiotics or any new complementary treatment within 3 months of recruitment, will be excludedThe control group will be surgically interfered with by breast augmentation or shrinking womenWomen with a history of cancer, gynaecological or endocrinology, as well as those who have received antibiotics within 3 months of recruitment, will also be excludedBlood, urine, breast tissue and stool samples will be collectedWe will collect data on anthrocometrics, sociodemographics, reproductive history, tumor characteristics and eating habitsMetabolomics studies will be conducted on samples of fecal and breast tissueIn addition, metagenomic studies of stool and breast tissue samples will be conducted to identify viral, fungal, bacterial and paleobacteria populations in the microbiomeEstrogens, estrogen metabolites and EDCs from serum, urine and breast tissue samples are also quantified
This is the first time in the same study that the contribution of bacteria, bacteria, viruses and fungi, as well as changes in environmental pollutants to breast cancer risk, have been assessedThe results will help to clarify risk factors, improve prognosis, and propose new interventional studies on the disease