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    Home > Active Ingredient News > Digestive System Information > BMC Gastroenterology: Correlation between adult waist-to-height ratio and non-alcoholic fatty liver disease

    BMC Gastroenterology: Correlation between adult waist-to-height ratio and non-alcoholic fatty liver disease

    • Last Update: 2021-06-01
    • Source: Internet
    • Author: User
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    In recent decades, with the rapid changes in social and economic development and life>non-alcoholic fatty liver disease (NAFLD) is a sharp rise in prevalence worldwide.
    It is estimated that more than a quarter of individuals in the world have NAFLD, which has become one of the most common chronic diseases.
    However, because injuries from NAFLD are usually chronic and asymptomatic, the actual prevalence may be underestimated.
    Therefore, the early detection of important risk factors for NAFLD is an urgent clinical need to be addressed.
    Waist circumference (WC) and body mass index (BMI) are currently the most widely used indicators to assess obesity and NAFLD.
    In recent years, in-depth studies have found that waist circumference to height ratio (WHTR) can better assess central obesity and
    diabetes , High blood pressure and other metabolic diseases.
    Therefore, this study aims to explore the relationship between WHtR and NAFLD.

    In recent decades, with the rapid changes in social and economic development and life>non-alcoholic fatty liver disease (NAFLD) is a sharp rise in prevalence worldwide.
    Non-alcoholic fatty liver diabetes

     


    This study included a total of 14,125 participants.
    In order to more intuitively understand the association between WHtR and NAFLD, the researchers grouped WHtR values ​​into quintiles and used a multivariate logistic regression model to evaluate WHtR and its quintiles.
    Digits and NAFLD risk.
    In addition, a generalized additive model is used to model the relationship between WHtR and NAFLD to explore the nonlinear relationship between them.

     


    The prevalence of NAFLD among the participants in this study was 17.
    59%, and the average age was 43.
    53±8.
    89 years.
    Researchers found that for every unit increase in WHtR, the risk of NAFLD increased by 66%.
    In addition, in the WHtR quintile array, the participants with the 1st quintile, the 2nd quintile, the 3rd quintile, the 4th quintile, and the 5th quintile The risk of NAFLD increased 3.
    62 times, 5.
    98 times, 9.
    55 times and 11.
    08 times, respectively.
    Non-linear relationship analysis revealed the threshold and saturation effects between WHtR and NAFLD.
    WHtR about 0.
    4 may be the threshold effect of NAFLD risk, and 0.
    6 may be the saturation effect of NAFLD risk.
    In addition, subgroup analysis showed that the interaction between WHtR and BMI is significant.

    Figure: The incidence of WHtR and NAFLD presents threshold and saturation effects

    Figure: The incidence of WHtR and NAFLD presents threshold and saturation effects


      The results of this study show that in adults, WHtR is associated with an increased incidence of NAFLD, and the association is not purely linear but non-linear, with significant threshold and saturation effects.

      The results of this study show that in adults, WHtR is associated with an increased incidence of NAFLD, and the association is not purely linear but non-linear, with significant threshold and saturation effects.

     

     

    Original source

    Guotai Sheng.
    Et al.
    biomedcentral.
    com/articles/10.
    1186/s12876-021-01824-3" target="_blank" rel="noopener">Waist-to-height ratio and non-alcoholic fatty liver disease in adults.
    BMC Gastroenterology.
    2021.

    biomedcentral.
    com/articles/10.
    1186/s12876-021-01824-3" target="_blank" rel="noopener">Waist-to-height ratio and non-alcoholic fatty liver disease in adults.
    BMC Gastroenterology.


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