BMC Immunol: Blood components in pregnant women can effectively prevent pathological immune responses

11, 2021 /--- -- A team of scientists from the Institute of Ecology and Microbiological Genetics at the Urals of the Russian Academy of Sciences (Perm) studied the role of beta-glycoprotein-promoting immune cells in the blood of pregnant women.
nourishing cell beta 1-glycoprotein, the female body does not adversely affect the fetus and supports its normal development until birth.
that nourishing cell beta 1-glycoprotein also inhibits the development of inflammatory lymphocytes and reduces their activity.
results of this work can be used to develop drugs for the maintenance of pregnancy and the treatment of various autoimmune diseases.
(Image source: www.pixabay.com) For pregnant women, fetal-related antigens are also foreign.
, however, there is a natural protection mechanism that prevents the mother's immune system from fighting the fetus and helps it adapt to the presence of the fetus.
this is due to a good balance between the anti-inflammatory and anti-inflammatory components, Th17 and Treg groups of lymphocytes.
Th17 lymphocytes belong to auxiliary cells that support other immune cells and can be identified by the presence of CD4 subjects.
, Treg lymphocytes inhibit the activity of the immune system.
That Treg cells dominate during normal pregnancy, and if any problems occur, the number of Th17s begins to increase.
increase in the proportion of
" Th17 is associated with pre-eclampsia, which can lead to elevated blood pressure, edema and increased protein in urine in pregnant women and, in severe cases, multiple organ failure.
addition, an increase in Th17 may be the cause of eclampsia, premature birth, miscarriage or repeated pregnancy, the cause of which is unknown.
Even in relatively normal pregnancy, elevated levels of Th17 can interfere with the development of the baby's nervous system and lead to a higher risk of neuropsychiaction," explains Larisa Litvinova.
Th17 immunomodulation disorder is the cause of autoimmune diseases such as asthma, psoriasis, rheumatoid arthritis, Crohn's disease (chronic intestinal inflammation), multiple sclerosis, etc.
, these diseases are less serious for pregnant women.
team concluded that pregnant women must produce active substances to fight inflammation not only caused by the presence of the fetus, but also by actual diseases.
these substances are called beta-1-glycoproteins, a special protein-carbohydrate molecule that regulates innate and adaptive (or obtainable) immunity.
the authors of this study tested the effects of these compounds on CD4 plus lymphocytes with specific receptors.
, the team took intravenous blood from healthy 21-39-year-olds.
, immune cells are isolated from the blood and cultured with nourishing beta-1-glycoprotein.
that nourishing cell beta 1-glyoprotein inhibits the division of CD4 plus lymphocytes and the production of cytokines.
these results, the authors recommend using drugs containing nourishing beta-1-glycoprotein to prevent pregnancy complications and save the lives and health of mothers and children.
(Bioon.com) Source: Substance in the blood of the women's fights pathological immune immune original source: Valeria P. Timganova et al, The effects of humane-specific beta 1-glycoprotein development on Th17 polarization of CD4 plus cells and their cytokine profile, BMC Immunology (2020). DOI: 10.1186/s12865-020-00385-6