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BMC Infect Dis: The effect of maternal poliovirus antibodies on infant immune response to poliovirus vaccine

 Last Update: 2021-07-28
 Source: Internet
 Author: User

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Maternal polio virus antibodies can provide passive immunity to newborns , protecting them from polio virus infection in the first few months of life , but they may also impair the infant’s immune response to the polio virus vaccine
.

In this study, the researchers compiled data from three clinical trials of an inactivated polio vaccine (IPV) based on the Sabin strain to study the effect of maternal polio antibodies on the immune response of infants to polio vaccine.

Immune infection

The study summary analysis includes five groups: low-dose Sabin IPV, medium-dose Sabin IPV, high-dose Sabin IPV, control Sabin IPV and control Salk IPV group
.

Two methods are used to reclassify infants in different groups.

The results showed that the GMTs and GMIs of the three types of polio virus antibodies in the participants with negative maternal antibodies were significantly higher than those of the participants with positive maternal antibodies
.

The seroconversion rates of type II and type III poliovirus antibodies of the maternal antibody-positive participants were significantly lower than those of the maternal antibody-negative participants

In summary, maternal polio virus antibodies can interfere with the infant's immune response to polio virus vaccine, and high levels of maternal antibodies show greater inhibition

Original source:

Siyue Jia, et al.

The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines in this message

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