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BMC Med: Apatinib + Oxaliplatin + Capecitabine Neoadjuvant Therapy for Locally Advanced Gastric Cancer/Gastroesophageal Junction Cancer

 Last Update: 2022-05-25
 Source: Internet
 Author: User

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Gastric cancer is one of the most common and deadly cancers in China

stomach cancer

Patients with advanced gastric cancer are often treated with drugs

Blood vessel

This study is a single-center, single-arm Phase 2 clinical trial conducted in Shanghai Fudan Zhongshan Hospital, recruiting patients with locally advanced (cT3/4aN+M0) gastric or gastroesophageal junction (GEJ) adenocarcinoma for three courses of treatment of oxaliplatin (135 mg/m2, D1), capecitabine (1000 mg/m2, 2/day, D1-14) and apatinib (250 mg/day, double the dose for the third cycle) Treatment, plus a course of oxaliplatin and capecitabine, followed by gastrectomy + D2 lymphadenectomy

Screening objective response rate was 78.

hypertension

In conclusion, the combination regimen of apatinib, oxaliplatin, and capecitabine as neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma showed reliable efficacy and controllable safety, and it is worth developing 3 Phase clinical trials for further validation

The combination regimen of apatinib, oxaliplatin and capecitabine as neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma showed reliable efficacy and controllable safety .

Tang Zhaoqing,Wang Yan,Yu Yiyi et al.

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