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Colorectal cancer (CRC) is one of the most common cancers in adults worldwide.
The International Agency for Research on Colorectal Cancer (IARC), the American Institute of Cancer Research (AICR) and the World Cancer Research Fund (WCRF) believe that obesity is a possible cause of CRC.
MAYO CLINIC
MAYO CLINICIn addition, limited data from observational studies indicate that weight loss can reduce the risk of CRC in postmenopausal women.
In addition, limited data from observational studies indicate that weight loss can reduce the risk of CRC in postmenopausal women.
Researchers studied the sex- and site-specific associations between fat and CRC risk, and whether fat-related metabolites can explain the association between fat and CRC.
BMI, WHR and CRC risk (58,221 CRC patients and 67,694 controls registered in the GECCC, CCTS, and CCFR studies) were subjected to gender combination and gender-specific Mendelian randomization (MR).
The purpose and hypothesis of the research.
The purpose and hypothesis of the research.
In the gender-specific MR analysis, the higher BMI of men was closely related to the increased risk of CRC (HR=1.
The relationship between BMI and WHR and CRC risk based on two MR samples.
The relationship between BMI and WHR and CRC risk based on two MR samples.
BMI or WHR are respectively related to 104/123 metabolites, but the positive correlation direction of the fat-CRC relationship is not consistent.
The higher the male BMI, the greater the female WHR, and the higher the risk of CRC.
references:
springer.
springer.
com/epdf/10.
1186/s12916-020-01855-9?sharing_token=l1sWq2mDPdn7KJBOQM_0lm_BpE1tBhCbnbw3BuzI2RN405EG3ixoScnavngIAMWGSLfWGX_ToyA0j2RdRv77qT4AG5rpzQLYdB6WKX370ttYKbCYqxbZoWJu81pKY_HQ7seQVHlcXPyCu5FoSbpzXZpPvbj8f7AXmIiR4F6h2vY%3D" target="_blank" rel="noopener">Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.
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