BMC Med: Recovery of serum testosterone levels is an accurate predictor of COVID-19 survival in male patients

Background: The COVID-19 pandemic is caused by SARS-CoV-2, and its clinical manifestations are diverse, including an exacerbated inflammatory state with tissue and organ destruction beyond the direct cytopathic effect of the virus

Background: The COVID-19 pandemic is caused by SARS-CoV-2, and its clinical manifestations are diverse, including an exacerbated inflammatory state with tissue and organ destruction beyond the direct cytopathic effect of the virus

The underlying mechanisms underlying the possible gender differences in the onset of severe COVID-19 are not fully understood

Sex dityping of immune responses to pathogens has long been recognized, pointing to stronger antiviral mechanisms, stronger T regulatory cells, and more innate lymphoid cells (ILC2) in women than in men as well as better immune-mediated tissue repair capabilities

Objective: To better understand the relationship between testosterone status and disease severity, we analyzed the relationship between serum biomarkers, including testosterone and immune cell subsets, and disease prognosis in patients with COVID-19

Methods: Biochemical and hematological parameters of admission samples from 497 hospitalized male and female COVID-19 patients were analyzed to understand their association with prognosis and gender

Table 1 Baseline clinical characteristics of the male study population

Table 2 Baseline clinical characteristics of the female study population

Table 2 Baseline clinical characteristics of the female study population

Figure 1 Clinical biochemical characteristics of male (A, C) and female (B, D) COVID-19 patients correlated with outcomes

Figure 1 Clinical biochemical characteristics of male (A, C) and female (B, D) COVID-19 patients correlated with outcomes

Figure 2 Assessment of clinical biochemical parameters as predictors of risk of severe illness or death from COVID-19

Figure 2 Assessment of clinical biochemical parameters as predictors of risk of severe illness or death from COVID-19

CONCLUSIONS: In male patients, recovery or failure to recover testosterone levels was strongly associated with survival or death, respectively

Original source: Toscano-Guerra E, Gallo MM, Arrese-Muñoz I, et al.
Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients.
BMC Med 2022 03 29;20(1) Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients.


Leave a comment here