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Obesity is an important risk factor for at least 13 different types of cancer.
diabetes
Metabolomics is an established technology that simultaneously measures multiple metabolites in human biological fluids or tissues to identify metabolic changes and biomarkers to understand pathophysiological processes.
Recently, in a study published in the journal BMC Medicine, researchers from the International Agency for Research on Cancer of the World Health Organization and the University of Leeds in the United Kingdom identified the metabolic characteristics of larger bodies and investigated their association with two types of obesity.
Colorectal cancer
The study used targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Survey of Cancer and Nutrition (EPIC) cohort and 17 individuals in a one-arm preliminary weight loss intervention study (Intercept).
The results of the study found that after multiple comparisons and adjustments, larger BMI, WC, and WHR were compared with higher levels of valine, isoleucine, glutamic acid, (diacylphosphatidylcholine) PC aa C38:3 and PC aa C38:4 is related to lower levels of asparagine, glutamine, glycine, serine, (acyllysophosphatidylcholine) lysoPC C17:0, lysoPC C18:1, lysoPC C18:2, (diacyl) Phosphatidylcholine) PC aa C42:0, (acyl alkyl phosphatidylcholine) PC ae C34:3 , PC ae C40:5 and PC ae C42:5 are related.
PC ae C34:3 , PC ae C40:5 and PC ae C42:5 BMI (OR1-sd 1.
Discover the association between concentrated metabolites and BMI, WC and WHR
Discover the association between concentrated metabolites and BMI, WC and WHRPearson correlation coefficient between BMI, WC and WHR PLS scores and their load
Pearson correlation coefficient between BMI, WC and WHR PLS scores and their loadThe relationship between colorectal cancer and endometrial cancer and the metabolic characteristics of obesity
The relationship between colorectal cancer and endometrial cancer and the metabolic characteristics of obesityMetabonomics characteristics, metabolite changes and weight loss of obesity in the initial intervention of Intercept
Metabonomics characteristics, metabolite changes and weight loss of obesity in the initial intervention of InterceptThe researchers pointed out that, consistent with previous studies, the current analysis shows that larger body size is related to the amino acids valine, leucine, isoleucine, tyrosine, glutamic acid, and the biogenic amine kynurenine.
diagnosis
Consistent with other studies, the metabolic characteristics of obesity reflect lipid regulation disorders, such as higher levels of diacyl PCs and lower levels of acyl-alkyl PCs.
diacyl PCs
Importantly, the metabolic profile of the larger WHR is positively correlated with the risk of endometrial cancer, regardless of the individual's body fat.
Intercept weight loss intervention has promoted the decline of amino acids and biogenic amines that have been positively correlated with obesity and cancer risk, such as tyrosine, phenylalanine, glutamic acid and kynurenine, indicating that obese people suffer from cancer after weight loss.
In summary, this study shows that obesity is associated with unique metabolic characteristics, including changes in specific amino acids and lipid levels, which are positively correlated with colorectal cancer and endometrial cancer, and may be reversed after weight loss.
Obesity is associated with unique metabolic characteristics, including changes in specific amino acids and lipid levels, which are positively correlated with colorectal cancer and endometrial cancer, and may be reversed after weight loss.
Nathalie Kliemann, Vivian Viallon et al.
biomedcentral.
com/articles/10.
1186/s12916-021-01970-1" target="_blank" rel="noopener">Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition.
BMC Med.
2021 Apr 30;19(1):101.
doi: 10.
1186/s12916-021-01970- 1.
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