BMC Med: What is the relationship between vitamin C and cancer risk?

Vitamin C is a basic micronutrient rich in fruits and vegetables, and is essential for many physiological processes of humans

Vitamin C is a basic micronutrient rich in fruits and vegetables, and is essential for many physiological processes of humans

Whether lifelong exposure to high physiological concentrations of vitamin C has a protective effect on cancer is still largely unknown

Observational research supports the inverse relationship between circulating vitamin C and cancer

So far, there is no MR analysis for these problems

The researchers used aggregate-level data from the large vitamin C genome-wide association study ( GWAS ) meta-analysis of genetic variants associated with plasma vitamin C, as well as data from the GWAS consortium related to lung, breast , prostate, colon, and rectal cancer.

GWAS breast cancer colon cancer

Two-sample two-way Mendelian randomization (MR) analysis was performed using the inverse variance weighting method as the main method, and six other methods (such as MR-Egger, weighted median and model-based methods) were used as sensitivity analysis Detect and adjust for polymorphism

Two-sample two-way Mendelian randomization (MR) analysis was carried out using the inverse variance weighting method as the main method, and six other methods (such as MR-Egger, weighted median and mode-based methods) were used as sensitivity analysis Detect and adjust for polymorphism

Overview of experimental design

The results showed that there is no evidence that circulating vitamin C levels are causally related to any cancers tested

The results showed that there is no evidence that circulating vitamin C levels are causally related to any cancers tested

There is no strong evidence that any cancers being checked and circulation of vitamin C have a causal relationship

A meta-analysis of the prospective association between vitamin C intake and cancer incidence in specific sites

In addition, a meta-analysis of prospective associations of diet or vitamin C supplementation with cancer risk still yielded invalid results

In addition, a meta-analysis of prospective associations of diet or vitamin C supplementation with cancer risk still yielded invalid results

Taken together, these findings provide no evidence to support that physiological levels of circulating vitamin C have a significant impact on the risk of the five most common cancers

references:

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.


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