BMI1: Overcome the apoptosis that occurs in adifferent embryos with human pluripotent stem cells.

Pan Guangjin of the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences made new progress in the study of human pluristem stem heterogeneous, with the results of the BMI1 enablessss sie chimerism with human pluripotent cells published on November 7 in the academic journal Nature Communications.
is expected to obtain functional cells, including pancreatic cells, hematopoietic stem cells, and so on, from human pluripotent stem cells in alien chimerics.
generally believe that the state of pluripotent stem cells consists of two, naive-shaped and primed states; only the naive-state pluripotent stem cells have the ability to enticate, compared with the cells in the primed state.
and human-enabled stem cells (hPSCs), which are routinely maintained in the laboratory, are considered primed.
the study found that primed hPSCs apoptosis occurs when primed hPSCs are transplanted into mouse blastocies, and that by expressing BMI1 gene in primed hPSCs can effectively inhibit the apoptosis of primed hPSCs in mouse blastocysts;
, primed hPSCs, which over-expression BMI1, can also produce chimerics in the blastocysts of rabbits and pigs.
notable, the researchers found that BMI1's high expression and anti-apoptosis ability are also important signs of the heterogeneous chimeric ability of naive hPSCs.
researchers compared the naive hPSCs obtained by comparing two different methods and found that only naive hPSCs with high BMI1 expression and single cloning to survive against apoptosis were effective lysacination.
the study shows that apoptosis is an important obstacle to the heterogeneous chimeric of human pluripotent stem cells, while BMI1 can effectively overcome the apoptosis that occurs in heterogeneous embryos, thus promoting heterogeneous chimerics.
the research was supported by the Chinese Academy of Sciences' strategic pilot project, the national key research and development plan, the Guangdong Science and Technology Program, etc.
Source: Guangzhou Institute of Biomedicine and Health.