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BMJ: Can dexamethasone reduce complications or all-cause mortality after non-cardiac surgery?

 Last Update: 2021-06-08
 Source: Internet
 Author: User

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More than 300 million major surgical operations are performed every year worldwide.

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Major surgery can cause local and systemic inflammation.

There are two mechanisms that explain why corticosteroids can reduce the risk of major postoperative complications.

In order to evaluate the effect of dexamethasone on the complication or mortality after major non-cardiac surgery, some investigators conducted a perioperative period of cortical therapy to treat non-cardiac surgery morbidity and mortality (PACMAN) stage III A randomized controlled trial, the results of which were recently published in the journal BMJ.

1222 adults (50 years old) who required major non-cardiac surgery were included, and the expected operation time was more than 90 minutes.

Among the 1,222 participants who received randomization, 1184 (96.

Subgroup analysis of complications or all-cause mortality 14 days after major non-cardiac surgery

Subgroup analysis of complication or all-cause mortality 14 days after major non-cardiac surgery Subgroup analysis of complication or all-cause mortality 14 days after major non-cardiac surgery Subgroup analysis

In conclusion, in this multicenter, double-blind, randomized controlled trial, postoperative dexamethasone in patients undergoing major non-cardiac surgery was not associated with a significant reduction in complications and mortality at 14 days after surgery.

Reference: Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
BMJ 2021; 373 doi: https://doi.
org/10.
1136/bmj.
n1162 (Published 02 June 2021)Cite this as: BMJ 2021;373:n1162 References: Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
BMJ 2021; 373 doi: https:/ /doi.
org/10.
1136/bmj.
n1162 (Published 02 June 2021)Cite this as: BMJ 2021;373:n1162 Reference: Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
BMJ 2021; 373 doi: https://doi.
org/10.
1136/bmj.
n1162(Published 02 June 2021) Cite this as: BMJ 2021;373:n1162 References: Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
BMJ 2021; 373 doi: https://doi.
org/10.
1136/bmj.
n1162 (Published 02 June 2021)Cite this as: BMJ 2021;373:n1162 Reference: Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial.
BMJ 2021; 373 doi: https://doi.
org/10.
1136/bmj.
n1162 (Published 02 June 2021)Cite this as: BMJ 2021;373:n1162doi: https://doi.
org/10.
1136/bmj.
n1162

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