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    Home > Active Ingredient News > Study of Nervous System > BMJ: Dietary addition of n-3 and n-6 ​​fatty acids can relieve migraine headaches in adults

    BMJ: Dietary addition of n-3 and n-6 ​​fatty acids can relieve migraine headaches in adults

    • Last Update: 2021-07-30
    • Source: Internet
    • Author: User
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    Although the treatment of migraine has improved in the past decade, many patients continue to suffer severe pain and disability despite taking multiple medications
    .
    Like many multifactorial chronic diseases, the incomplete understanding of the underlying biological mechanisms limits the development of effective
    prevention and treatment methods
    .

    Although the treatment of migraine has improved in the past decade, many patients continue to suffer severe pain and disability despite taking multiple medications
    .
    Like many multifactorial chronic diseases, the incomplete understanding of the underlying biological mechanisms limits the development of effective
    prevention and treatment methods
    .
    prevention

    Christopher E Ramsden et al.
    published an article in the BMJ magazine to explore whether dietary interventions that increase n-3 fatty acids and do not decrease n-6 linoleic acid can change the circulating lipid mediators related to the onset of headaches, thereby reducing headaches in adult migraine patients

    .

    Christopher E Ramsden et al.
    published an article in the BMJ magazine to explore whether dietary interventions that increase n-3 fatty acids and do not decrease n-6 linoleic acid can change the circulating lipid mediators related to the onset of headaches, thereby reducing headaches in adult migraine patients

    .

    Established a 16-week ambulatory academic medical center in the United States
    .
    182 participants (88% were women, with an average age of 38) suffered from migraine 5-20 days a month (67% met the criteria for chronic migraine)

    .

    Established a 16-week ambulatory academic medical center in the United States
    .
    182 participants (88% were women, with an average age of 38) suffered from migraine 5-20 days a month (67% met the criteria for chronic migraine)

    .

    Intervention measures: Three diets designed with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and linoleic acid as control variables: H3 diets (n=61) increase EPA+DHA To 1.
    5g/d, linoleic acid is maintained at about 7% of energy; H3-L6 diet (n=61)-increasing n-3EPA+DHA to 1.
    5g/d, reducing linoleic acid’s energy accounted for ≤1.
    8% ; Control diet (n=60)-maintain EPA+DHA at <150 mg/day, and linoleic acid at about 7% of energy

    .
    All participants received food that accounted for two-thirds of daily food energy and continued daily care

    .

    Intervention measures: Three diets designed with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and linoleic acid as control variables: H3 diets (n=61) increase EPA+DHA To 1.
    5g/d, linoleic acid is maintained at about 7% of energy; H3-L6 diet (n=61)-increasing n-3EPA+DHA to 1.
    5g/d, reducing linoleic acid’s energy accounted for ≤1.
    8% ; Control diet (n=60)-maintain EPA+DHA at <150 mg/day, and linoleic acid at about 7% of energy

    .
    All participants received food that accounted for two-thirds of daily food energy and continued daily care

    .

    The primary endpoint (week 16) is the blood analgesic agent 17-hydroxydocosahexaenoic acid (17-HDHA) and the headache impact test (HIT-6), which is a six-item assessment of the impact of headache on quality of life Questionnaire
    .
    Use an electronic diary to assess the frequency of headaches every day

    .

    The primary endpoint (week 16) is the blood analgesic agent 17-hydroxydocosahexaenoic acid (17-HDHA) and the headache impact test (HIT-6), which is a six-item assessment of the impact of headache on quality of life Questionnaire
    .
    Use an electronic diary to assess the frequency of headaches every day

    .

    The effect of diet on precursor fatty acids

    The effect of diet on precursor fatty acids

    In the intention-to-treat analysis (n=182) , the circulating 17-HDHA (log ng/ml) increased in the H3-L6 and H3 diets compared with the control diet (baseline adjusted mean difference 0.
    6, 95% confidence interval, respectively) They are 0.
    2~0.
    9, 0.
    7, 0.
    4~1.
    1)

    .
    The improvement in HIT-6 scores observed in the H3-L6 and H3 groups was not statistically significant (-1.
    6, -4.
    2 to 1.
    0, and -1.
    5, -4.
    2 to 1.
    2, respectively)


    .


    In the intention-to-treat analysis (n=182) , the circulating 17-HDHA (log ng/ml) increased in the H3-L6 and H3 diets compared with the control diet (baseline adjusted mean difference 0.
    6, 95% confidence interval, respectively) They are 0.
    2~0.
    9, 0.
    7, 0.
    4~1.
    1)

    .
    The improvement in HIT-6 scores observed in the H3-L6 and H3 groups was not statistically significant (-1.
    6, -4.
    2 to 1.
    0, and -1.
    5, -4.
    2 to 1.
    2, respectively)


    .





    The daily headache time is related to precursor fatty acids and oxidized lipids

    The daily headache time is related to precursor fatty acids and oxidized lipids

    Compared with the control diet, the H3-L6 and H3 diets reduced the total number of headache hours per day (-1.
    7, -2.
    5 to -0.
    9 and -1.
    3, -2.
    1 to -0.
    5, respectively), and reduced the number of moderate to severe headache hours per day (Respectively -0.
    8, -1.
    2 to -0.
    4 and -0.
    7, -1.
    1 to -0.
    3), reduced the number of headache days per month (respectively -4.
    0, -5.
    2 to -2.
    7 and -2.
    0, -3.
    3 to -0.
    7)

    .
    The H3-L6 diet reduces the number of headache days more than the H3 diet (-2.
    0, -3.
    2--0.
    8), which indicates that
    reducing the linoleic acid in the diet has additional benefits
    .
    H3-L6 and H3 diets changed n-3 and n-6 ​​fatty acids and several noxious oxygenated lipid derivatives in plasma, serum, red blood cells or
    immune cells, but did not change the classic headache mediator calcitonin gene-related Peptides and prostaglandin E2

    .
    H3-L6 and H3 interventions changed the biologically active mediators related to the onset of headaches, reduced the frequency and severity of headaches, but did not significantly improve the quality of life
    .

    Compared with the control diet, the H3-L6 and H3 diets reduced the total number of headache hours per day (-1.
    7, -2.
    5 to -0.
    9 and -1.
    3, -2.
    1 to -0.
    5, respectively), and reduced the number of moderate to severe headache hours per day (Respectively -0.
    8, -1.
    2 to -0.
    4 and -0.
    7, -1.
    1 to -0.
    3), reduced the number of headache days per month (respectively -4.
    0, -5.
    2 to -2.
    7 and -2.
    0, -3.
    3 to -0.
    7)

    .
    The H3-L6 diet reduces the number of headache days more than the H3 diet (-2.
    0, -3.
    2--0.
    8), which indicates that
    reducing the linoleic acid in the diet has additional benefits
    .
    H3-L6 and H3 diets changed n-3 and n-6 ​​fatty acids and several noxious oxygenated lipid derivatives in plasma, serum, red blood cells or
    immune cells, but did not change the classic headache mediator calcitonin gene-related Peptide and prostaglandin E2
    immunity
    .
    H3-L6 and H3 interventions changed the bioactive mediators related to the onset of headaches, reduced the frequency and severity of headaches, but did not significantly improve the quality of life
    .

    In summary, the study tested two positive dietary interventions aimed at the known biochemical mechanisms that regulate nociceptive sensations
    .
    Both diets produced biochemical changes consistent with reduced sensation of harm

    .
    Although these diets did not significantly improve the quality of life, they significantly reduced the frequency and severity of headaches compared to the control diet

    .
    In some results, the H3-L6 diet is more effective than the H3 diet

    .
    This study provides a biologically credible proof that pain can be treated with targeted dietary changes

    .
    This discovery indicates a causal mechanism between n-3 and n-6 ​​fatty acids and nociceptive sensations, and opens the door to new ways to
    manage chronic pain in humans
    .

    In summary, the study tested two positive dietary interventions aimed at the known biochemical mechanisms that regulate nociceptive sensations
    .
    Both diets produced biochemical changes consistent with reduced sensation of harm

    .
    Although these diets did not significantly improve the quality of life, they significantly reduced the frequency and severity of headaches compared to the control diet

    .
    In some results, the H3-L6 diet is more effective than the H3 diet

    .
    This study provides a biologically credible proof that pain can be treated with targeted dietary changes

    .
    This discovery indicates a causal mechanism between n-3 and n-6 ​​fatty acids and nociceptive sensations, and opens the door to new ways to
    manage chronic pain in humans
    .
    In summary, the study tested two positive dietary interventions aimed at the known biochemical mechanisms that regulate nociceptive sensations
    .
    Both diets produced biochemical changes consistent with reduced sensation of harm

    .
    Although these diets did not significantly improve the quality of life, they significantly reduced the frequency and severity of headaches compared to the control diet

    .
    In some results, the H3-L6 diet is more effective than the H3 diet

    .
    This study provides a biologically credible proof that pain can be treated with targeted dietary changes

    .
    This discovery indicates a causal mechanism between n-3 and n-6 ​​fatty acids and nociceptive sensations, and opens the door to new ways to
    manage chronic pain in humans
    .
    manage

    Original source

    Original source

    Dietary alteration of n-3 and n-6 ​​fatty acids for headache reduction in adults with migraine: randomized controlled trial.
    BMJ 2021; 374 doi:
    https://doi.
    org/10.
    1136/bmj.
    n1448 

    https://doi.
    org/10.
    1136/bmj.
    n1448 


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