BMJ: Effects of BODY Mass Index in Adolescence on Cardiovascular, Diabetes and Tumor Risk in Later Life

Researchers recently assessed the effect of body mass index in adolescence on the risk of developing later liferesearchers collected data from the British Biobank and four large-scale genome-wide association studies (GWAS), which included 453,169 participants, and the GWAS study, which involved more than 700,000 participants, measured their BMI at age 56.5 and reported their BMI at age 10The main endpoints of the study were coronary artery disease, type 2 diabetes, breast cancer and prostate cancersingle-variable Mendel randomization analysis showed that higher BMI in adolescence was associated with an increased incidence of coronary artery disease (1.49) and type 2 diabetes (2.32)However, based on the multivariate Mendel randomization study, BMI had no significant effect on the risk of coronary artery disease (1.02) and type 2 diabetes (1.16) in adolescence, but higher BMI in adolescence reduced the risk of breast cancer (0.59) and no effect son-in-law of bmi on prostate cancer risk was found in adolescentsstudies suggest that higher body mass index in adolescence or a lower risk of breast cancer