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Endoscopic retrograde pancreatic bile tube anthosis (ERCP) is a common endoscopic examination method with many therapeutic effects, but not without potential complications.
incidence of ERCP is usually 5% to 10%.
ERCP post-ERCP pancreatitis (PEP) is the most common and worrying complication, with an incidence and mortality rate of 9% and 3%, respectively.
There are currently a number of strategies to reduce PEP risk, including active fluid resuscitation, PD stent implantation, use of urethane, statins, trypsin, antibiotics, rectal anti-inflammatory pain and epinephrine, etc.
on the use of epinephrine, an experiment has shown that spraying epinephrine on the nipples can reduce the risk of PEP.
, the study aims to compare the differences between rectal anti-inflammatory pain drugs plus epinephrine (EI) and rectal anti-inflammatory pain plus sterile water (WI) in preventing PEP.
the multi-center randomized controlled trial included patients older than 18 years of age with ERCP.
all patients were treated with 100 mg of rectal anti-inflammatory pain and 10 ml of sterile water or 1:10,000 epinephrine dilution.
the patient's PEP symptoms by telephone 24 hours and 7 days after the operation.
then perform a statistical analysis.
3,054 of the 3,602 patients were excluded from the study.
the remaining 548 patients were randomly divided into EI group (n s 275) or WI group (n s 273).
baseline characteristics of two groups of patients in the EI and WI groups were similar.
PEP in patients in the EI group was similar to that in the WI group (3.6% (10/275) VS 5.12% (14/273), p s 0.41).
study found that the insertion of pancreatic catheter wire was identified as a risk factor for PEP (OR 4.38,95% CI (1.44 to 13.29), p s 0.009).
researchers concluded that spraying epinephrine on nipple sphides alone in patients with ERCP did not alone prevent papulitis after endoscopic retrograde pancreatic bile tube blastitis.
