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    Home > Active Ingredient News > Digestive System Information > BMJ Gastroenterology: Loss of skeletal muscle mass can affect the incidence of mild liver encephalopathy

    BMJ Gastroenterology: Loss of skeletal muscle mass can affect the incidence of mild liver encephalopathy

    • Last Update: 2020-12-16
    • Source: Internet
    • Author: User
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    Hepatocephalopathy (HE) is a serious complication of cirrhosis that reduces the quality of life (QOL) of patients.
    least HE (MHE) is no HE symptoms, i.e. clinically no obvious neuropsychiastic symptoms, can only be diagnosed with sensitive neuropsychological and neurophysiological examinations.
    the difficulty of diagnosis will gradually increase, not only affecting QOL, but also affecting the patient's prognosis.
    to improve these results, MSE needs to be detected early.
    is a typical substance that induces liver encephalopathy.
    in patients with cirrhosis, the metabolism of ammonia in the liver decreases.
    , muscles play an important role in ammonia breakdown.
    as a result, a decrease in muscle mass can lead to a deterioration in ammonia metabolism.
    , ammonia itself is reported to inhibit protein synthesis in muscles.
    , muscle reduction is bad in terms of muscle metabolism because it involves a loss of skeletal muscle mass and strength.
    little is known about whether muscle reduction and/or muscle mass loss are associated with the smallest liver encephalopathy (MHE).
    study is intended to study this.
    researchers included 99 patients with cirrhosis in the trial.
    the diagnosis of MHE is confirmed by a neuropsychotic examination.
    The skeletal mass index (SMI) and lumbar muscle index (PMI) are calculated by divided the skeletal muscle area and lumbar muscle area of the third lumbar spine by the square of the height in meters.
    then compare the correlation between muscle reduction and MHE.
    61 cases for men and 38 for women out of 99 patients.
    MHE was 48 (48.5%) and muscle reduction was 6 (6.1%).
    patients were divided into two groups, depending on the patient having or not having MSE.
    no significant difference in serum concentration or the rate of amyopathy.
    patients with MHE (46.4 cm2/m2) had an SMI smaller than those without MHE (51.2 cm2/m2, P=0.027).
    , PMI for those with MHE is also smaller (4.24cm2/m2) than those without (5.53cm2/m2, P s 0.003).
    skeletal muscle volume, expressed in SMI or PMI, is an MHE-related predictive factor (SMI≥50 cm2/m2; The ratio ratio is 0.300, P is 0.002, pmI≥ 4.3 cm2/m2; ratio of 0.192, P-0.001).
    the study's final authors: The decline in muscle mass is associated with minimal liver encephalopathy, and measuring muscle mass loss may help predict the occurrence of MHE and intervene early.
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