BMJ Gastroenterology: The relapse of disease after moderate to severe ulcerative colitis in fecal bacteriologic group transplantation and the efficacy of fecal cytos transplantation

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes persistent inflammation and ulcers in the digestive tract, and current treatments are primarily aimed at inducing and maintaining clinical and endoscopic remission.
possible pathogenesis of UC involves changes in the composition of the intestinal bacteri, known as "bacterial disorders", which can cause the mucous membrane immune system to activate, leading to chronic inflammation of the mucous membranes.
, fecal microbiome transplantation (FMT), which can rebalance the bacteriota, has become an effective method for treating mild to moderately active UCs.
that although FMT has been performed in the medical facilities where the researchers are based since 2017, it has achieved good results in UC treatment.
but in clinical work, they found that the efficacy of FMT decreased significantly after the recurrence of the disease in UC patients with FMT.
researchers looked at all UC patients who received FMT at their clinic and selected 12 moderate to severe UC patients.
received multiple FMTs and followed up for 52 weeks.
, they don't have any other underlying diseases.
all patients underwent colonoscopy and used SCCAI and UDCAI scores to assess the effectiveness of FMT treatment.
results show that, overall, FMT has an important effect on moderate to severe UC.
of the 12 patients, 11 (91.7%) achieved clinical remission, 9 (75.0%) achieved clinical remission, and only 1 patient did not respond to FMT treatment.
, six cases relapsed within 52 weeks of remission, with a recurrence rate of 54.5%.
6 patients received FMT again, but the efficacy of FMT after recurrence was significantly lower than that of the initial FMT.
, the severity of the disease after recurrence was significantly reduced compared to prior to the initial FMT treatment.
study confirms that FMT has a good effect on moderate to severe UC mitigation.
, the effect of FMT therapy again after recurrence is reduced.
for patients who relapse after remission, the efficacy of applying FMT again requires more experiments to verify.
Xiao-Fei Dang. Et al. Recurrence of moderate to severe ulcerative colitis after fecal microbiota transplantation treatment and the efficacy of re-FMT: a case series. BMJ Gastroenterology.2020.MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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