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How did you spend that long night? Insomnia is a major public health problem affecting 10%–30% of the general population globally, and it can be a concomitant symptom of many medical, neurological and psychiatric disorders
.
Type 2 diabetes (T2DM) is a chronic disease that affects 500 million people worldwide today and is expected to increase by 25% by 2030 and 51% by 2045
.
There is evidence from observational studies that people with insomnia have a higher risk of developing T2DM
.
Recently, two specific Mendelian randomized (MR) studies supported an adverse effect of insomnia on the risk of T2DM, suggesting that insomnia is a novel cause of T2DM
.
However, little is known about the mechanisms linking insomnia and T2DM
.
This study applied a network Mendelian randomization (MR) framework to determine the causal relationship between insomnia and T2DM and to identify potential factors including body mass index (BMI), waist-to-hip ratio and body fat percentage and glucose metabolism (HbA1c, fasting blood glucose and fasting insulin)
.
We selected 1,331,010 study individuals from UK and EU databases and used the MR framework to examine effect estimates for insomnia-T2DM, insomnia-mediator, and mediator-T2DM associations
.
If MR studies confirm a causal relationship between insomnia and T2DM, then a mediator between insomnia and T2DM is established
.
The results showed that insomnia was associated with increased risk of T2DM in inverse variance weighting, with no heterogeneity and no horizontal pleiotropy, strongly suggesting a causal relationship between genetically predicted insomnia and T2DM
.
Furthermore, the MR analysis provided strong evidence for a causal relationship between insomnia and BMI and body fat percentage
.
There is also some evidence for a link between insomnia and waist-to-hip ratio
.
At the same time, the findings suggest that there is no causal relationship between insomnia and glucose metabolism
.
Higher BMI, waist-to-hip ratio, and body fat percentage levels were strongly associated with increased risk of T2DM
.
The causal relationship between genetically determined insomnia and T2DM Network MR maps of overweight and glucose metabolism summary in insomnia to type 2 diabetes In summary, the findings suggest a causal relationship between genetically predicted insomnia and type 2 diabetes
.
Being overweight (especially BMI and body fat percentage) is a causal pathway from insomnia to type 2 diabetes
.
Reference: Xiuyun W, Jiating L, Minjun X, et al Network Mendelian randomization study: exploring the causal pathway from insomnia to type 2 diabetes BMJ Open Diabetes Research and Care 2022;10:e002510.
doi: 10.
1136/bmjdrc-2021-002510 Written | Edited by liangying | Swagpp Click "read the original text" below to download the Mace Medical APP
.
Type 2 diabetes (T2DM) is a chronic disease that affects 500 million people worldwide today and is expected to increase by 25% by 2030 and 51% by 2045
.
There is evidence from observational studies that people with insomnia have a higher risk of developing T2DM
.
Recently, two specific Mendelian randomized (MR) studies supported an adverse effect of insomnia on the risk of T2DM, suggesting that insomnia is a novel cause of T2DM
.
However, little is known about the mechanisms linking insomnia and T2DM
.
This study applied a network Mendelian randomization (MR) framework to determine the causal relationship between insomnia and T2DM and to identify potential factors including body mass index (BMI), waist-to-hip ratio and body fat percentage and glucose metabolism (HbA1c, fasting blood glucose and fasting insulin)
.
We selected 1,331,010 study individuals from UK and EU databases and used the MR framework to examine effect estimates for insomnia-T2DM, insomnia-mediator, and mediator-T2DM associations
.
If MR studies confirm a causal relationship between insomnia and T2DM, then a mediator between insomnia and T2DM is established
.
The results showed that insomnia was associated with increased risk of T2DM in inverse variance weighting, with no heterogeneity and no horizontal pleiotropy, strongly suggesting a causal relationship between genetically predicted insomnia and T2DM
.
Furthermore, the MR analysis provided strong evidence for a causal relationship between insomnia and BMI and body fat percentage
.
There is also some evidence for a link between insomnia and waist-to-hip ratio
.
At the same time, the findings suggest that there is no causal relationship between insomnia and glucose metabolism
.
Higher BMI, waist-to-hip ratio, and body fat percentage levels were strongly associated with increased risk of T2DM
.
The causal relationship between genetically determined insomnia and T2DM Network MR maps of overweight and glucose metabolism summary in insomnia to type 2 diabetes In summary, the findings suggest a causal relationship between genetically predicted insomnia and type 2 diabetes
.
Being overweight (especially BMI and body fat percentage) is a causal pathway from insomnia to type 2 diabetes
.
Reference: Xiuyun W, Jiating L, Minjun X, et al Network Mendelian randomization study: exploring the causal pathway from insomnia to type 2 diabetes BMJ Open Diabetes Research and Care 2022;10:e002510.
doi: 10.
1136/bmjdrc-2021-002510 Written | Edited by liangying | Swagpp Click "read the original text" below to download the Mace Medical APP
