BMJ Sub-Journal: A prospective study of over 450,000 people over 11 years reveals the relationship between random blood glucose and all-cause mortality in healthy adults

Diabetes is an important death risk factor for a series of vascular and non-vascular diseases, including ischemic heart disease (IHD), stroke, chronic kidney disease (CKD) and infectious diseases
.

Although there is sufficient evidence that the risk of death from cardiovascular disease (CVD) is lower when the blood glucose level is lower than the diagnostic threshold of diabetes , the relationship with other specific causes of death is far from clear .

Although the blood vessels of diabetes have sufficient evidence to show that when the blood sugar level is lower than the diagnostic threshold of diabetes , the risk of death from cardiovascular disease (CVD) is lower, but the relationship with other specific causes of death is far from clear

In recent decades, the prevalence of urinary disease and pre-diabetes in China has increased rapidly, highlighting the importance of blood sugar as a risk factor

This study investigated the relationship between long-term routine random blood glucose (RPG) levels and cause-specific mortality risk in Chinese adults without diabetes
.

From 2004 to 2008, Kadoorie Biobank recruited 512,891 adults (59% female) aged 30-79 years old in 10 regions of China

This study investigated the relationship between long-term routine random blood glucose (RPG) levels and cause-specific mortality risk in Chinese adults without diabetes

The results showed that during an average follow-up of 11 years, 37,214 of the 452,993 participants who had not previously been diagnosed with diabetes or other chronic diseases died

Predicted absolute mortality of selected major diseases based on usual random blood glucose levels

Selected predict major diseases is calculated in the usual random blood glucose level of absolute mortality predict major diseases selected calculated in the usual random blood glucose levels absolute mortality rates for selected major diseases calculated in the usual random blood glucose levels predict mortality in absoluteusual Predicted absolute mortality of selected major diseases calculated by random blood glucose level

In summary, among participants without diabetes, there is a positive log-linear relationship between RPG levels and CVD, CKD, chronic liver disease, cancer, and all-cause mortality.
This relationship runs through the entire blood glucose test range, and diabetes is excluded during follow-up.
Persistent after the patient
.

This provides insights into the underlying etiology and suggests that blood glucose may provide useful information for predicting the risk of death

In summary, among participants without diabetes, there is a positive log-linear relationship between RPG levels and CVD, CKD, chronic liver disease, cancer, and all-cause mortality.

References: References: References: VermuntJ ,BraggF ,HalseyJon behalf of the China Kadoorie Biobank Collaborative Group VermuntJVermunt BraggFBragg HalseyJHalsey on behalf of the China Kadoorie Biobank Collaborative Group on behalf of the China Kadoorie Biobank Collaborative Group on behalf of the China Kadoorie Biobank Collaborative Group, et al.
BMJ Open Diabetes Research and Care2021;9:e002495.
  doi: 10.
1136/bmjdrc-2021-002495.
doi:10.
1136/bmjdrc-2021-002495.
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