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    Home > Active Ingredient News > Endocrine System > BMJ Sub-Journal: Tumor necrosis factor-related protein-3 (CTRP3) concentration is associated with diabetic peripheral neuropathy!

    BMJ Sub-Journal: Tumor necrosis factor-related protein-3 (CTRP3) concentration is associated with diabetic peripheral neuropathy!

    • Last Update: 2022-05-11
    • Source: Internet
    • Author: User
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    Diabetes is a worldwide pandemic, with more than 700 million people projected to be diagnosed with diabetes worldwide by 2045, and more importantly, the incidence of several chronic diabetes complications is also increasing


    Diabetes is a worldwide pandemic, with more than 700 million people projected to be diagnosed with diabetes worldwide by 2045, and more importantly, the incidence of several chronic diabetes complications is also increasing


    pixabay.


    pixabay.


    Epidemiological data show that the estimated prevalence of DPN in patients with type 2 diabetes mellitus (T2DM) is 28.


    Substantial evidence suggests that type 2 diabetes and its chronic complications are strongly associated with increased inflammatory burden


    A total of 347 participants were recruited for this study, plasma CTRP3 concentrations were analyzed in DPN (n=172) and non-DPN (n=175) subjects, nerve conduction tests and oral glucose tolerance tests were performed, and all participants were finally measured The Neuropathic Symptom Score (NSS)/Neuropathy Disability Score (NDS) and biochemical parameters


    A total of 347 participants were recruited for this study, plasma CTRP3 concentrations were analyzed in DPN (n=172) and non-DPN (n=175) subjects, nerve conduction tests and oral glucose tolerance tests were performed, and all participants were finally measured The Neuropathic Symptom Score (NSS)/Neuropathy Disability Score (NDS) and biochemical parameters


    The results showed that plasma CTRP3 concentrations were significantly lower in DPN patients than in diabetic patients without DPN (p < 0.


    Plasma CTRP3 concentrations in non-DPN and DPN patients

    Plasma CTRP3 concentrations in non-DPN and DPN patients

    In conclusion, the results of this study showed that plasma CTRP3 concentration was significantly reduced in DPM patients and was positively correlated with nerve conduction velocity


    In conclusion, the results of this study showed that plasma CTRP3 concentration was significantly reduced in DPM patients and was positively correlated with nerve conduction velocity


    References: LinK ,YangL ,XiongY , et al.


    References: Lin  K ,  Yang  L ,  Xiong  Y , et al.
    Plasma C1q/tumor necrosis factor-related protein-3 concentrations are associated with diabetic peripheral neuropathy.
    BMJ Open Diabetes Research and Care  2022; 10: e002746.
      doi:  10.
    1136/ bmjdrc-2021-002746 Reference: Lin  K ,  Yang  L ,  Xiong  Y Lin  K Lin Yang  L Yang Xiong  Y Xiong , et al.
    BMJ Open Diabetes Research and Care  2022; 10:e002746.
      doi:  10.
    1136/bmjdrc-2021-002746 doi:

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