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Borane is also called borohydride compound, because its physical properties are similar to alkanes, so it is called borane
In organic organic synthesis laboratories, borane is mostly used as a reducing agent
1.
(1) The chemical properties of borane are very active.
(2) Borane is very toxic.
2.
(1) Borane has high spontaneous combustion and cannot be exposed to air
(2) Borane will burn violently in contact with water and air, so the sampling and feeding must be protected with nitrogen and kept away from the water source
(3) When quenching the reaction with water ( usually saturated brine) or methanol , be sure to stir well and ensure that it is under the protection of nitrogen flow.
(4) For reactions exceeding 500mL, use mechanical stirring.
(5) To ensure the ventilation effect, avoid the explosion limit,
Three, examples
Application process: Add BH 3 ·Me 2 S dropwise to the methylene chloride solution (-5°C) in which the raw material carboxylic acid A is dissolved , and then increase the temperature to 25°C.
Remarks: During the application process, a large amount of reaction heat will be released at a certain moment, the temperature will rise sharply, a large amount of gas will be emitted, the boiling point of dichloromethane is low, and the heat capacity is small, which is easy to cause flushing and combustion accidents