Br J Anaesth: The relationship between plasma tau protein and the incidence and severity of postoperative delirium

background

Postoperative delirium is related to the increase of neurogenic cellulose (NFL), a biomarker of nerve cell damage
.
This study verified two other biomarkers, glial fibrillary acidic protein (GFAP: an intermediate filament protein expressed in astrocytes) and tau (τ protein: a microtubule-associated protein that regulates axis Whether the stability of the protruding microtubules is related to postoperative delirium

method

A total of 114 surgical patients were recruited to evaluate the severity and incidence of postoperative delirium
.
Collect plasma samples for biomarker analysis, including tau protein, NfL and GFAP, and 10 cytokines

result

GFAP concentration has nothing to do with delirium
.
The change in plasma tau protein concentration in patients with delirium from preoperative to the first day after surgery was greater (P<0.

in conclusion

The change of plasma tau protein is related to the incidence and severity of postoperative delirium, and it alleviates over time
.
The impact of this biomarker of perioperative neuronal injury on long-term cognitive function deserves further study

Original source:

Ballweg T, et al.