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Br J Cancer: A randomized clinical trial study of TARGIT-IORT (targeted intraoperative radiotherapy during breast cancer lumpectomy)

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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Most breast cancer patients are generally suitable for breast-conserving surgery and adjuvant radiotherapy, rather than total mastectomy.

Breast cancer researchers proposed the concept of TARGeted intraoperative radiotherapy (TARGIT-IORT).

The TARGIT-IORT trial aims to achieve accurate positioning and rapid formation of tumor focus radiotherapy strategies , which only focus on target tissues, so that normal tissues and organs (such as heart, lung, skin and chest wall structures) are protected from unnecessary and potential Destructive radiation therapy.

TARGIT-IORT trial aims to achieve accurate positioning and rapid formation of tumor focal radiotherapy strategies TARGIT-IORT trial aims to achieve accurate positioning and rapid formation of tumor focal radiotherapy strategies

Researchers designed a randomized trial of TARGIT-A.

Targeted intraoperative radiotherapy (TARGIT-IORT), which is risk-adapted during breast cancer lumpectomy, is as effective as total breast external beam radiotherapy (EBRT).

Forest plot shows the local recurrence-free survival rate and overall survival rate of tumor subgroups

The results showed that there was no difference in the local recurrence-free survival rate between TARGIT-IORT and EBRT in each tumor subgroup.

Unlike the EBRT group, the local recurrence rate in the TARGIT-IORT group is not a higher predictor of the remote recurrence rate or the risk of death.

Subgroup analysis of the overall survival rate of cancer patients of each grade

All in all, the results of the study revealed that in all subgroups, TARGIT-IORT was as effective as the EBRT treatment strategy.

The results of the study revealed that in all subgroups, TARGIT-IORT was as effective as the EBRT treatment strategy.

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